Confirm an association between RA and periodontitis and unravel pathogenic mechanisms underlying this association.
ID
Source
Brief title
Condition
- Autoimmune disorders
- Bacterial infectious disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The Dutch Periodontal Screenig Index (DPSI) (van der Velden 2009).
Secondary outcome
Disease Activity Score 28 joint count (DAS28)
Eastman Interdental Bleeding Index (EIB, Caton&Polson 1985)
Visible plaque index (VPI, Ainamo&Bay 1975)
ACPA titer
Anti-Pg titer
Presence of Porphyromonas gingivalis
Presence of ACPAs in gingivocrevicular (GCF)
Presence of HLA DR/DQ
Leucocyte count, ESR, CRP
Background summary
Rheumatoid arthritis (RA) and periodontitis are chronic inflammatory disorders
characterized by disregulation of the host inflammatory response. Increased
secretion of proinflammatory mediators results in soft and hard tissue
destruction of the synovium and periodontium respectively. The etiology of both
diseases is multifactorial, and they share risk factors like smoking, ageing
and certain ge-polymorphisms. Studies have shown the prevalence of
periodontitis is higher in RA patients, and that periodontal therapy can reduce
the disease activity of RA. Sequence similarity and cross-reactivity with
immunodominant epitopes of citrullinated proteins and their bacterial variants,
and/or molecular mimicry of antibodies may indicate a role for bacterial
infection, particularly with the periodontal pathogens P. gingivalis, in
priming autoimmunity in a subset of patients with RA.
Study objective
Confirm an association between RA and periodontitis and unravel pathogenic
mechanisms underlying this association.
Study design
An observational study on the prevalence of periodontitis in RA patients,
analysing clinical parameters and biomarkers of both diseases. Biomarkers will
be assessed in peripheral blood, subgingival plaque and gingivocrevicular
fluid. In case of periodontal or orthopaedic surgery this will also be done in
gingival and synovial tissue.
Study burden and risks
Potential benefit: detection of periodontitis.
Antonius Deusinglaan 1
9713AV
NL
Antonius Deusinglaan 1
9713AV
NL
Listed location countries
Age
Inclusion criteria
Study group: RA patients
1. Fulfilling the American College of Rheumatology classification criteria for RA (1987).
2. Age > 18 years.
Control group: individuals without RA, aged >18 years.
Exclusion criteria
According to the SENIEUR protocol (1984):
1. Infection or inflammation other than periodontitis or RA.
2. Present malignancy.
3. Other conditions which influence the immune system: diabetes, active thyroid disease, myocardial infarction, stroke or recanalisation of the femoral arteries for claudication <6 months prior to the study.
4. Pregnancy including a 6-months post-partem period as well as breastfeeding.
5. Malnutrition.
6. Alcoholism and drug abuse.
7. Pharmacological interference: use of corticosteroids >10mg/dag, antibiotic use during 3 months prior to the study.
8. Edentulism.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL36033.042.11 |