To study the test-retest reliability effects on three fMRI tasks administered in the ePOD project in children (aged 10-14) and adults (aged 23-30).
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
het onderzoek betreft geen aandoening
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Difference in accuracy (ICC; intra-class correlation coefficients) between
first and second scanning session for voxels located within the activated
network.
Secondary outcome
N.a.
Background summary
When performing serial testing it is of crucial importance to know the
occurrence of test-retest effects such as practice effects, and whether these
differ between children and adults. However, there is limited literature on the
re-test effects of task-related functional MRI (fMRI), particularly in children
(Kelly and Garavan et al., 2005). The current project aims to study potential
re-test effects on three fMRI tasks administered in the ongoing ePOD project.
In the ePOD (effects of Psychotropic drugs On the Developing brain) project we
investigate the effects of age following chronic treatment with fluoxetine
(Prozac®) and methylphenidate (Ritalin®) in clinical trials in children,
adolescents and young adults (NL. 26402.000.09 and NL 34509. 000.10).
Study objective
To study the test-retest reliability effects on three fMRI tasks administered
in the ePOD project in children (aged 10-14) and adults (aged 23-30).
Study design
Non-invasive longitudinal two time point study
Study burden and risks
MRI itself is a non-invasive imaging modality, which is frequently employed
also in healthy children aged 8 years and older in the Netherlands (Prof. Crone
LUMC *Hersenen in actie*:
http://www.juniorhersenen.nl/index.php/meedoen-aan-onderzoek) and also at the
AMC (e.g., METC 06/207). The nature of the burden is classified as minimal,
considering that subjects will have to come to the AMC for 45 minutes on two
occasions. The risks involved are negligible, as all the techniques employed
are registered for their use and/or routinely performed at the AMC.
Meibergdreef 9
1105 AZ
NL
Meibergdreef 9
1105 AZ
NL
Listed location countries
Age
Inclusion criteria
12 healthy girls aged 12-14 years
12 healthy young women aged 23-30 years
12 heathy boys aged 10-12 years
12 healthy young males aged 23-30
Exclusion criteria
A history of neuropsychiatric disease. Contraindications for MRI (e.g. osteosynthetic material, pacemaker, artificial cardiac valves); claustrophobia.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL35557.018.11 |