The main objective of the current study is to determine the short-term effects of a glucose drink and a sacharose drink on memory, attention and mood in elderly men women.
ID
Source
Brief title
Condition
- Disturbances in thinking and perception
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary outcome will be the difference in memory after the glucose drink
and the sacharose drink versus the placebo drink. Different sensitive memory
tests will be used.
Secondary outcome
Next to the effect of glucose and sacharose on memory, the effect on attention
will be measured by performing a high-demanding attention task. Furthermore,
mood will be assessed by the POMS-questionnaire. Blood glucose response will be
determined, even as blood levels of insulin.
Background summary
Glucose is the main metabolic fuel for the brain and as such plays a role in
the modulation of cognitive processes. Several studies already showed an
enhancing effect of glucose drinks on memory, however not all results are
consistent. Research towards the effect of sacharose, the daily intake of
glucose, on memory is scarce. Furthermore, the effect of both glucose and
sacharose on attention is not clear up till now. Also mood seems to be
influenced by the intake of glucose drinks. By investigating the effect of
glucose and sacharose on memory, attention and mood we will contribute to a
better understaning of cognitive functioning.
Study objective
The main objective of the current study is to determine the short-term effects
of a glucose drink and a sacharose drink on memory, attention and mood in
elderly men women.
Study design
A counterbalanced, repeated-measures study design will be used, in which
subjects will be exposed to three different test conditions in a
counterbalanced order. Test sessions will have at least one week in between to
minimize learning effects. Before consuming the test drink, participants will
fill in a questionnaire about mood. Furthermore, a venapunction will be carried
out on the first test day. Blood glucose levels will be measured at five time
points (t=0, 15, 30, 45, 90). Fifteen minutes after consuming the test drink a
cognitive test battery will be performed.
Intervention
Three different test drinks will be consumed at three different time moments; a
glucose drink (50 g), a sacharose drink (100 g) and a saccharine drink (23,7
mg) serving as the placebo. All drinks contain 240 ml of water and will have
the same taste and appearence by adding 10 ml of lemon juice.
Study burden and risks
Participants will visit the university three times for approximately 2.5 hours
after an overnight fast. During the first visit, blood samples will be
collected by a venapunction, which may cause a small hematoma. Furthermore,
blood glucose levels will be measured on five timepoints by using a finger
prick. Participants will conduct several cognitive performance tests, which may
be experienced as difficult.
Amsterdamsestraatweg 39A
3744 MA Baarn
NL
Amsterdamsestraatweg 39A
3744 MA Baarn
NL
Listed location countries
Age
Inclusion criteria
Elderly women and men >= 70 years
Memory complaints
Able to understand and perform study procedure
Exclusion criteria
• Type I or type II diabetes (fasted blood glucose level >= 7,0 mmol)
• Parkinson disease
• MMSE < 25 (to exclude cognitively impaired subjects)
• CES-D score > 16 (to exclude depressive subjects)
• Pharmacological antidepressiva or medication for dementia
• Liver disease
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL36813.081.11 |