The aim of this MRI study is to understand how neurodegeneration in MS (in vivo) is related to other facets of MS pathology, i.e. inflammatory (T2) lesions, black hole (T1) lesions, cortical lesions and damage of the normal appearing brain tissue.…
ID
Source
Brief title
Condition
- Autoimmune disorders
- Demyelinating disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Global and local atrophy measures will be obtained from high resolution
T1-weighted images. Conventional MR images of the brain and spinal cord, and 3D
DIR images will be used to detect and classify MS lesions. Advanced MRI
techniques, namely DTI and T1 relaxation-time mapping, will be used to quantify
tissue damage in normal appearing brain tissue, and relations between these
parameters will be assessed.
Secondary outcome
Not applicable.
Background summary
Classically, multiple sclerosis (MS) has been approached as a *typical*
inflammatory demyelinating disease of the central nervous system. Recent
evidence has however suggested that neurodegeneration plays a critical role in
the pathogenesis and severity of the disease. Unfortunately, to date the cause
or starting point of neurodegeneration is unknown, and much is unclear about
the variable phenotypic expression of neurodegenerative pathology in MS.
Study objective
The aim of this MRI study is to understand how neurodegeneration in MS (in
vivo) is related to other facets of MS pathology, i.e. inflammatory (T2)
lesions, black hole (T1) lesions, cortical lesions and damage of the normal
appearing brain tissue. To achieve our goal, we propose to perform an extensive
MRI study measuring different properties of the brain in the various disease
phenotypes and study the relations between the observed neurodegeneration and
pathology globally, regionally and voxel-wise.
Study design
This study is a prospective, single-centre, observational cohort study
assessing the relation between neurodegeneration and other pathology in
patients with MS.
Study burden and risks
Participants are asked to come one day to our outpatient clinic to undergo an
exam to determine EDSS (approximately 30 minutes) and an MRI scan. The scan
will be made at our 3 Tesla MRI system and duration of the scan will be
approximately 60 minutes. Earplugs will be provided to reduce the noise of the
scanner. MRI examinations are considered to have negligible risks. Before the
examination, all participants will be screened for metal objects in their
bodies, risk of claustrophobia, or other MRI contraindications. No
interventions will take place in this study.
De Boelelaan 1117
1081 HV Amsterdam
NL
De Boelelaan 1117
1081 HV Amsterdam
NL
Listed location countries
Age
Inclusion criteria
- Age 18-65 years
- Clinically definite MS (based on Polman criteria, 2005)
- Need to meet the safety criteria to undergo an MRI examination
Exclusion criteria
For all participants:
- History of drug abuse
- Psychiatric disease
- Claustrophobia
- Pregnancy
- Foreign non MR compatible metal objects in the body
- Foreign metal objects in or close to the head;Aditionally for the patients:
- Other neurological disorders besides MS
- Relapses and/or steroid treatment in the four weeks prior to the examination;Additionally for the healthy controls:
- Neurological disorders
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL36722.029.11 |