We will identify factors that interfere with the beneficial effects of exercise on the vasculature in T2DM.
ID
Source
Brief title
Condition
- Coronary artery disorders
- Diabetic complications
- Arteriosclerosis, stenosis, vascular insufficiency and necrosis
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The effect of an increase in the exercise-induced shear stress on the
post-exercise endothelial function (as measured with the brachial artery
flow-mediated dilation) in subjects with T2DM
The effect of hyperglycaemia on post-exercise endothelial function (as measured
with the brachial artery flow-mediated dilation) in T2DM.
Secondary outcome
Not applicable
Background summary
Endothelial dysfunction contributes to the development of vascular
complications in type 2 Diabetes Mellitus (T2DM). Exercise training improves
endothelial function, and in this improving process shear stress is a key
factor. T2DM show an impaired shear stress to exercise. This prevents an
optimal effect of training, which may be restored by increasing the
exercise-induced shear stress.
Shear stress leads to the production of nitric oxide, a strong dilator with
anti-atherogenic effects. Hyperglycaemia impairs the shear stress signaling
pathway, leading to a smaller NO production and preventing the beneficial
effects of exercise on the endothelial function in T2DM.
Study objective
We will identify factors that interfere with the beneficial effects of exercise
on the vasculature in T2DM.
Study design
Cross-sectional observational study
Study burden and risks
5 minutes of cuff occlusion will be employed to investigate endothelial
function. This is a non-invasive procedure and is not associated with any
health risks for the subject. We will also take three venous blood samples from
each subject. Subjects will perform a hand grip protocol, which can be somewhat
tiring, but is not associated with any health risks for the subject. Local
heating of the forearm (42*C) will be employed, and furtermore, subjects will
ingest 75 grams of glucose, which is the amount that is used in the very widely
applied Oral Glucose Tolerance Test, and therefore not expected to cause any
harm to the subject. Subjects do not benefit directly from participating in
this study.
Geert Grooteplein Noord 21
6525 EZ Nijmegen
NL
Geert Grooteplein Noord 21
6525 EZ Nijmegen
NL
Listed location countries
Age
Inclusion criteria
Older than 40 years
Diagnosed with type 2 diabetes mellitus at least 2 years ago
Exclusion criteria
Women
Cardiovascular disease
Hypercholesterolemia
Hypertension (>160 mmHg systolic and/or >90 mmHg diastolic pressure) and/or subjects on antihypertensive drugs
Smoking
Type I diabetes mellitus
Older than 65 years
Subjects with vascular complications due to type 2 diabetes mellitus (e.g. diabetic foot ulcer)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL36179.091.11 |