Decrease of carotid intima media thickness after bariatric surgery as marker of reduction of cardiovasculair disease.
ID
Source
Brief title
Condition
- Glucose metabolism disorders (incl diabetes mellitus)
- Gastrointestinal therapeutic procedures
- Arteriosclerosis, stenosis, vascular insufficiency and necrosis
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Reduction of carotid intima-media thickness after bariatric surgery.
Secondary outcome
- Reduction of visceral fat mass after bariatric surgery
- Anthropometric measurements and bloodpressure before and after bariatric
surgery
- Glucose, lipids and cholesterol profile before and after bariatric surgery
- Differences between the measurements and the three different types of
bariatric surgery.
Background summary
Obesity is associated with cardiovascular morbidity and mortality. Carotid
intima media thickness and viceral fat mass are prognostic indicators for
premature atherosclerosis and indicative for the development of cardiovascular
disease. Carotid intima media thickness is a accedive atherosclerotic parameter
and the measurement is easily done and non invasive.
Study objective
Decrease of carotid intima media thickness after bariatric surgery as marker of
reduction of cardiovasculair disease.
Study design
Observational study
Study burden and risks
Low
Groene Hilledijk 315
3075 EA Rotterdam
NL
Groene Hilledijk 315
3075 EA Rotterdam
NL
Listed location countries
Age
Inclusion criteria
Age between 18 en 60 years
BMI > 40 kg/m2 or BMI > 35 kg/m2 with co-morbidity (DM, cardiac or lung problems, joint complaints)
Several registrated efforts of weightloss, guarded by a dietician
Exclusion criteria
Leeftijd < 18 en > 60 jaar
Personality disorderd / alcohol- and drugsabuse
< 5 years of adiposity
No serious attempts of weightloss
Obesity caused by hormonal or metabolic disorders, no willingness for analysis of such disorders or lifelong check-ups
Change in medication to prevent atherosclerosis (statins).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL35522.101.11 |