Pilot study on additional value of 7T as compared to 3T MRI
ID
Source
Brief title
Condition
- Seizures (incl subtypes)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
visualy detectable abnormalities
Secondary outcome
Abnormality type and characteristics
Raise or not of found abnormalities after adding localizing information
provided by MEG
Background summary
With the use of stronger magnetic fields in MRI (from 0.5 to 3 T) the
percentage of patients with localisation related epilepsy in whom an underlying
abnormality can be detected (noteably a focal cortical dysplasia) has grown
(Von Oertzen). In addition, there are other functional investigational methods
available, like MEG, that can give a clue on the localization of an
epileptogenic focus (e.g. Ossenblok). At present MRI-machines with a field
strength of 7T beconme available for human investigations. It is still unclear
if this higher field strength can have an additional value in the diagnosis of
localisation related epilepsy or if the gain of detailed information and a
possible rise in artefacts will make diagnosis even more troublesome.
Study objective
Pilot study on additional value of 7T as compared to 3T MRI
Study design
Description of characteristics of known FCD when using 7T MRI
Blinded comparison of visual examination by neuroradiologist with specific
epilepsy experience and main investigator between MRI images of 3T vs 7T after
state-of the art acquisition.
Re-examination of both after adding MEG-acquired knowledge.
Study burden and risks
Burden: Time of travel and time spend inside of the MRI. Depending on location
of habitat of subject varying between 2 to 5 hours. Further more, subjects are
requested not to move several minutes for several times while being inside of
the scanner. This is standard procedure during MRI. As al subject already had
an MRI they know what to expect.
Risks: We will apply only sequences that are approved for use in humans. As far
as known there are no additional risks.
Sterkselseweg 65 postbus 61
5590 AB Heeze
NL
Sterkselseweg 65 postbus 61
5590 AB Heeze
NL
Listed location countries
Age
Inclusion criteria
localisation related epilepsy
3T MRI with FCD
OR
3T MRI negative and Plausible MEG focus
Age over 17
able to give consent
Exclusion criteria
contra-indications for MRI
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL31157.058.11 |