Optimization of a recently developed 3T MRI protocol for imaging of the coronary and aortic vessel wall.
ID
Source
Brief title
Condition
- Coronary artery disorders
- Arteriosclerosis, stenosis, vascular insufficiency and necrosis
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
1. Image quality: subjective and objective
2. Geometric measurement: vessel wall thickness, vessel wall area and lumen area
3. Reproducibility: intra- and interobserver agreement and interscan
reproducibility
Secondary outcome
not applicable
Background summary
Cardiovascular disease is the leading cause of morbidity and mortality
worldwide. The majority of vascular patients die from coronary atherosclerosis
rather than from extra coronary atherosclerosis. Therefore, it is important to
detect atherosclerosis in the coronary arteries and the aorta at an early
stage.
Study objective
Optimization of a recently developed 3T MRI protocol for imaging of the
coronary and aortic vessel wall.
Study design
The study is designed as a cross-sectional study. Subjects will undergo two MRI
scans in a period of four weeks. Subjects will undergo a 3T MRI scan of the
coronary and aortic vessel wall. To enhance the contrast between the vessel
wall and the surrounding tissue gadolinium contrast will be used. During the
study MRI parameters will be changed to yield the best possible image quality
and reproducibility.
Study burden and risks
There are minimal risks regarding the use of gadoliumn contrast. All healthy
volunteers will be screened on allergy for contrastagents and the renal
function will be assessed.
Furthermore, no short and long term adverse effects of the 3 T MRI scanner on
the human body are known.
Heidelberglaan 100
3584 CX Utrecht
NL
Heidelberglaan 100
3584 CX Utrecht
NL
Listed location countries
Age
Inclusion criteria
- healthy volunteers
- male or female
- 18 years or older
Exclusion criteria
- pregnancy or possible pregnancy
- lactation
- documented allergic reaction to gadolinium
- renal function below normal (GFR < 80ml/min/1.73m2)
- impossibility to undergo MRI (determined by using the standard contraindications for MR imaging as used for clinical purposes) .
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL32696.041.10 |