The main aim of this research is to search for sensitive and specific QEEG markers to differentiate between children with a developmental disorder, in this case ADHD and ASD, and a control group and to differentiate between these two developmental…
ID
Source
Brief title
Condition
- Developmental disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
QEEG measurements will be performed under four conditions in every participant:
resting condition eyes open, resting condition eyes closed, during an attention
task and during a motor task . QEEG profiles will be the main outcome measures.
Secondary outcome
Not applicable
Background summary
Diagnosing developmental disorders is a time consuming process. Until now, QEEG
measurements are not used in this process although QEEG profiles have proven to
be reliable indicators of different psychopathologies. Several studies have
shown that brain activation patterns of children with developmental disorders
like ADHD and ASD can be differentiated from brain activation patterns of
control children. Unfortunately different researchers use different equipment,
software and measurement settings. Because QEEG outcomes are very dependent on
these factors, data across studies and across studied groups cannot always be
compared.
Study objective
The main aim of this research is to search for sensitive and specific QEEG
markers to differentiate between children with a developmental disorder, in
this case ADHD and ASD, and a control group and to differentiate between these
two developmental disorders compared with each other. Besides this research
will look for the influence on the QEEG of comorbidities that are of current
interest like Gilles de la Tourette, dyslexia and DCD. To do so, the patient
groups and the control group will be measured with the same equipment, software
and measurement settings. In this way QEEG outcomes across groups can be
compared in a reliable and valid way.
By means of combining several (non)linear analysis methods QEEG markers for
every pathology will be examined and developed and sensitivity and specificity
measures of these markers will be calculated.
Additionally the effect of medication (methylphenidate) in children with ADHD
on the QEEG profile will be investigated.
Study design
The nature of the study is observational.
Study burden and risks
The burden and risks of this research are very minimal. QEEG measurements are
non-invasive measurements. Placing the electrodes on the scalp does not hurt
and also the measurement itself is painless. The total time it takes for a
child to participate does not exceed 45 to 60 minutes. If a child is using
medication (methylphenidate) for ADHD, the research will be conducted twice;
once with and once without medication. The total time for the research then
comes to 90 to 120 minutes.
Measurements will be conducted with medically certified equipment (class 2A).
Tegelseweg 210
5912 BL Venlo
NL
Tegelseweg 210
5912 BL Venlo
NL
Listed location countries
Age
Inclusion criteria
Boys between 6 and 12 years with the diagnosis of ADHD or ASD (autism spectrum disorder) conform DSM-IV criteria , with or without co-morbidities like Gilles de la Tourette, DCD or dyslexia.
Healthy boys between 6 and 12 years as controlgroup.
Exclusion criteria
Children with organic brain-defects, epilepsy, migraine, other psychiatric disorders than developmental disorders and children with influenza or fever.
Besides the boys in the controlgroup may not have any developmental disorders and should have normal results on the SDQ totalscore and subscores.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| Other | candidate nr.9326 Ned.Trial Register |
| CCMO | NL29647.068.10 |
| OMON | NL-OMON24766 |