To study the effect of pectin in 5 different physicochemical states on ad libitum energy intake and possible underlying mechanisms; i.e. gastrointestinal hormones, gastric emptying rate, feelings of satiety and the method of fiber supplementation.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
verzadiging, overgewicht
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
difference in ad libitum energy intake between pectin and control treatments.
Secondary outcome
differences in feelings of satiety, levels of gastrointestinal hormones,
gastric emptying time between treatments, and differences in type of fiber
supplementation.
Background summary
Dietary fibers have a relevant role in body weight management. Dietary fiber
may increase satiety and, as a consequence, reduce energy intake of the next
meal. There are, however, many different types of dietary fiber, which have
diverse physical properties and will therefore impact these outcomes
differently. It is important to study whether dietary fibers with different
properties lead to differences in energy intake during the next meal.
Study objective
To study the effect of pectin in 5 different physicochemical states on ad
libitum energy intake and possible underlying mechanisms; i.e. gastrointestinal
hormones, gastric emptying rate, feelings of satiety and the method of fiber
supplementation.
Study design
Blind, randomized crossover trial with 6 different treatments. Each subject
will receive a control and 5 fiber breakfasts. Before and after the breakfast,
blood samples, breath samples and satiety questions are taken every 15 or 30
minutes for 3 hours. After 3 hours, an ad libitum lunch will be consumed until
pleasantly satisfied.
Intervention
The breakfast will consist of a shake and 150 ml water. The composition of the
shakes are similar except for type of pectin: 1) no pectin; 2) low viscous, low
gelling; 3) high viscous, low gelling; 4) low viscous, high gelling; 5) low
viscous, high gelling (in 2 parts); 6) no pectin in shake, but low viscous,
high gelling pectin capsules that have to be ingested with the water. The
pectin is supplemented in 10g.
Study burden and risks
The intervention is non-therapeutic to the participant. The risk associated
with participation is negligible and the burden can be considered as minimal.
At screening the following measurements and questionnaires will be taken:
inclusion questionnaire (1x), Dutch Eating Behaviour Questionnaire (1x),
height, weight (1x), fasting glucose and Hb (1x). During the intervention
study, subjects will attend 6 testing days. Every day they ingest a breakfast
supplemented with pectin or placebo. Each day the following measurements and
questionnaires will be taken: appetite/satiety questionnaires over 3 hours
(12x), breath tests over 3 hours (12x), blood samples (9x) by means of a venous
cannula which is placed by a qualified nurse. After 3 hours, an ad libitum meal
will be provided, consisting of regular lunch items.
Bomenweg 4
6703 HD Wageningen
NL
Bomenweg 4
6703 HD Wageningen
NL
Listed location countries
Age
Inclusion criteria
healthy, as judged by the participant,
age: 18-30 years,
BMI : 18.5-25 kg/m^2
gender: male
Exclusion criteria
Gender: Female
Weight loss or weight gain of more than 5 kg during the last 2 months
Using an energy restricted diet during the last 2 months
Lack of appetite for any reason
Restrained eater
Smoking
Heavy alcohol use
Reported stomach or bowel disease
Reported diabetes
Reported thyroid disease or any other endocrine disorder
Reported intolerance for pectin, gluten, dairy
Anemia
Fasting glucose levels >5.8 mmol/l
Students and employees of the division of Human Nutrition
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL33684.081.10 |