To develop pulse transit time into a diagnostic device which can be used to assess an altered cold/heat mediated vasomotor response (CHMV) (central component) and the flow-mediated dilatation (FMD) (peripheral component) in CRPS patients.
ID
Source
Brief title
Condition
- Peripheral neuropathies
- Vascular disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Difference in PTT, as a result of cold-heat mediated vasomotor function within
subjects and between subjects. Difference in PTT, as a result of flow mediated
dilatation within subjects and between subjects. Standard error of measurement
and smallest detectable difference of PTT in controls and patients.
Relationship between severity of symptoms of CRPS patients and PTT measurement
in patients.
Secondary outcome
Relationship between severity of symptoms of CRPS patients and PTT measurement
in patients.
Background summary
Based on previous findings, the blood circulation in a CRPS1 involved limb can
be altered due to vasomotor dysfunction. This vasomotor dysfunction can be
caused by central and/or peripheral mechanisms. Clinically it is difficult to
determine the involved mechanism, prohibiting effective treatment. Therefore we
need equipment that can more reliable determine the cause of vasomotor
dysfunction, allowing a mechanism based treatment. The aim of this study: is
pulse transit time (PTT) a reliable tool to provide information about a
mechanism involved in vasomotor dysfunction in patients with CRPS1?
Study objective
To develop pulse transit time into a diagnostic device which can be used to
assess an altered cold/heat mediated vasomotor response (CHMV) (central
component) and the flow-mediated dilatation (FMD) (peripheral component) in
CRPS patients.
Study design
Observational single centre case-control study.
Study burden and risks
The risks are negligible. In this study we take measurement on the skin. Total
research will request one visit of approx. 1 hour and 45 minutes. There is no
direct benefit for the patient to participate in the study. Furthermore these
methods might elucidate aspects of the pathophysiology involved in CRPS.
Dr. Molewaterplein 50
3015 GE Rotterdam
NL
Dr. Molewaterplein 50
3015 GE Rotterdam
NL
Listed location countries
Age
Inclusion criteria
18 year and older
Diagnosed as CRPS according to the IASP criteria
One CRPS involved upper limb
Exclusion criteria
Without illness that effects vasomotor functioning
o Cardiovascular diseases
o Peripheral vascular disease
o Diabetes
o Muscle or skeletal injuries in upper limb
Incapacitated subjects
Haemopoetic disease
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL27847.078.09 |