Identifying translational EEG endophenotypes in mice and man that will determine cross-species genetic findings on behavioural and cognitive traits, including psychiatric disorders.
ID
Source
Brief title
Condition
- Psychiatric disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameters are obtained from electrophysiological data,
including spectral analysis of frequency bands during resting state, Event
Related Potentials, like P50, PPI and P300, but also connectivity with
coherence, and graph theory analysis. Correlations with behavioural and
cognitive measures will be explored, as well as associations with candidate
genes or genomic measures, like gene-expression, copy number variants and
chromosomal strains.
Secondary outcome
not applicable
Background summary
As the brain is central to the study of cognition, neuropsychiatric traits and
behaviour in all species, it is important to obtain standardized measures of
brain activity. New sophisticated analysis of EEG recordings can provide such
models for interspecies understanding of brain function in health and disease.
Therefore, studies integrating EEG measures are desperately needed.
For understanding the pathophysiology underlying the behavioural traits and
psychiatric disorders, we hope to identify susceptibility genes for analogous
endophenotypes across species. This approach can provide novel biological
pathways plus validated animal models critical for selective drug development.
Study objective
Identifying translational EEG endophenotypes in mice and man that will
determine cross-species genetic findings on behavioural and cognitive traits,
including psychiatric disorders.
Study design
The current study will be an observational pilot study in which we intend to
obtain standardized EEG recordings in a broad variety of animal and human
subjects. First, we will compare differences in a range of
electrophysiological outcome measures between human and animal groups using a
2x2 design (eg. comparing the difference between mice with and without the
bipolar disorder gene ADCY8 gene to the difference between bipolar disorder
patients and healthy controls). Secondly we will compare differences between
human participants with and without a genetic variant of interest (such as the
ADCY8 gene), with differences in EEG of animals with and without such genetic
variant.
Study burden and risks
Participation in this study will take two hours. Overall, the risks associated
with participation and the benefits to the individual are felt to be minimal.
EEG is a safe method, with no additional risks for the participants. The
potential benefit to society in the future is considerable if we are able to
effectively compare the animal and human data.
Heidelberglaan 100
3508 GA Utrecht
NL
Heidelberglaan 100
3508 GA Utrecht
NL
Listed location countries
Age
Inclusion criteria
- Subjects must fit in one of the groups that are investigated.
- Age >=18 and able to give consent
- Inclusion of patients with all Dutch ancestry (at least three of the four grandparents from the Netherlands)
- previous participation in studies, in which the participant has consented to be aproached for other studies
Exclusion criteria
- Age <18
- Premorbid IQ <80
- Presence of major somatic illness
- Current treatment or detention under the Dutch governmental mental health act.
- Participants that can not read, speak or understand Dutch.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL34331.041.10 |