We aim to answer the following research questions:Primary:1) Is a history of major depressive disorder associated with smaller volumes of the hippocampus and is this volume reduction disproportionate to the total brain volume?2) Are depression and…
ID
Source
Brief title
Condition
- Mood disorders and disturbances NEC
- Arteriosclerosis, stenosis, vascular insufficiency and necrosis
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Outcome variables for research question 1 are the volume of the hippocampus and
total brain volume on MRI.
Outcome variables for research question 2 are the small vessels on MRI.
Secondary outcome
Hypothalamic-pituitary-adrenal (HPA) axis, antidepressant medication, cognitive
functioning.
Background summary
Depression and cognitive decline are frequently observed and disabling
conditions in later life. Evidence exists that persons with major depressive
disorder have structural brain abnormalities. One of these brain structures is
the hippocampus. In stress-related disorders, such as depression, the
regulation of the stress hormone cortisol may be disturbed, which may lead to
increased levels of cortisol and damage to the hippocampus. Another potential
mechanism is changes in the small vessels in the brain. If these changes occur
in mood-regulating brain regions, this could result in mood disorders and
cognitive decline.
Study objective
We aim to answer the following research questions:
Primary:
1) Is a history of major depressive disorder associated with smaller volumes of
the hippocampus and is this volume reduction disproportionate to the total
brain volume?
2) Are depression and normal aging associated with cerebral small vessel
disease?
Secondary:
1) What is the rol of the HPA-axis in the relation between depression and
structural brain changes?
2) What is the rol of antidepressant medication in the relation between
depression and structural brain changes?
3) Are the potentially observed structural brain changes associated with
cognitive impairment?
Study design
Cross-sectional observational study.
Study burden and risks
The burden will consist of a visit to the UMC Utrecht on a normal weekday,
which will take about the whole day. The risks will be nausea or dizziness
after the MRI, and a small chance of hematoma resulting from venapunction.
These risks will not result in permanent damage, but only in short-term
discomfort. In addition, participants will fill in two questionnaires and
collect 5 saliva samples.
Postbus 85500
3508 GA Utrecht
NL
Postbus 85500
3508 GA Utrecht
NL
Listed location countries
Age
Inclusion criteria
1) All participants who were diagnosed with major depressive disorder in one or more measurements of the PREDICT study (03-177/O).
2) Participants without a diagnosis of major depressive disorder on any of the PREDICT measurements.
3) All PREDICT participants of 65 years or older.
Exclusion criteria
Contra-indications for MRI scan (metals in the body, claustrophobia, pregnancy). Dementia, psychosis, terminally ill, or physically unable to come to the UMCU as diagnosed by the general practitioner of the participant.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL32748.041.10 |