To investigate the acute effects of capsaicin on energy expenditure, substrate oxidation, appetite profile and ad libitum energy intake during negative energy balance.
ID
Source
Brief title
Condition
- Metabolism disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Energy expenditure, substrate oxidation, appetite profile and ad libitum energy
intake.
Secondary outcome
n.v.t.
Background summary
Red pepper might prevent reduction of energy expenditure and elevation of
hunger as a result of energy intake restriction.
Study objective
To investigate the acute effects of capsaicin on energy expenditure, substrate
oxidation, appetite profile and ad libitum energy intake during negative energy
balance.
Study design
The study will be conducted in a crossover design with four randomly sequenced
conditions. Energy expenditure and substrate oxidation will be continuously
monitored for 36h. Appetite profile will be measured hourly. Ad libitum energy
intake will be measured during the last meal.
Intervention
Subjects will stay for each of the four conditions in a respiration chamber for
36h, twice receiving an energy-balanced (100 En%) diet and twice an
energy-restricted (75 En%) diet, both with and without added capsaicin
(100%control, 75%control, 100%CAPS, 75%CAPS).
Study burden and risks
The study does not include any major risk for the subjects. Anthropometric and
body composition measurements, performed during the screening, will not be
invasive for the subjects. Deuterium dilution has been shown to be a safe
method for determining total body water. Furthermore, the registration of
oxygen consumption and carbon dioxide production in the respiration chamber
will be performed during an unconscious process. The air in the chamber is
continuously regulated.
Urine sampling will be done in urine bottles added with diluted HCl, which
might pose a risk for the subjects. However, subjects will be carefully
instructed how to handle the bottles to reduce these risks.
Additionally, there are no risks for the subject in consuming any of the
provided meals, because people with certain food allergies are excluded for
participation and all meals are composed of regular food items available in
normal Dutch supermarkets. The addition of capsaicin to the meals will not form
any health risk. Capsaicin is a natural product, which is safe in the given
dose that will not exceed the maximum recommended daily dose.
This study does not have any benefits for the subjects themselves, but will
give possible new knowledge for the treatment of obesity.
Postbus 616
6200 MD Maastricht
NL
Postbus 616
6200 MD Maastricht
NL
Listed location countries
Age
Inclusion criteria
Healthy, age 18-50 y, BMI 20-30 kg/m2, non-smoking, weight stable, dietary unrestraint
Exclusion criteria
Smoking, use of medication, more than moderate alcohol and/or caffeine consumption
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL35339.068.11 |