In this study we aim to examine the relationship between certain potential risk factors and the development of Parkinson Disease: environmental exposure to pesticides, exposure to extremely low frequency electromagnetic fields, and the role of…
ID
Source
Brief title
Condition
- Movement disorders (incl parkinsonism)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main parameters in this study are life-time exposure to pesticides,
ELF-EMF, and certain specific gene mutations or polymorphisms. These parameters
will be compared between cases and controls.
Secondary outcome
1
Background summary
Parkinson Disease is one of the most prevalent neurodegenerative diseases.
Pesticide application in agriculture is an established risk factor for
Parkinson Disease. We aim to investigate environmental pesticide exposure as a
risk factor for Parkinson Disease and other Parkinsonisms, using modeled
exposure at the self-reported life-time residential addresses of the study
subjects. Another less-studied potential risk factor for Parkinson Disease is
extremely low frequency electromagnetic fields (ELF-EMF), e.g. from power lines
or electric equipment, which will be the second focus of our study. In
addition, we will study the role of genetic factors and gene-environmental
interactions in the development of Parkinsonisms. For this DNA will be isolated
from saliva samples and analyzed for several selected candidate genes.
Study objective
In this study we aim to examine the relationship between certain potential risk
factors and the development of Parkinson Disease: environmental exposure to
pesticides, exposure to extremely low frequency electromagnetic fields, and the
role of genetics.
Study design
The study will be a multi-centre hospital-based case-control study.
Study burden and risks
After informed consent, all study subjects will be interviewed in a structured,
computer-assisted telephone interview. Furthermore, those who consent, receive
a simple self-collection-kit and are asked to send their saliva sample back by
mail for genetic analysis. Both the interview and the collection of saliva are
non-invasive, safe, and not a high burden for the subjects.
Postbus 90151
5000LC Tilburg
NL
Postbus 90151
5000LC Tilburg
NL
Listed location countries
Age
Inclusion criteria
Inclusion criteria for cases:
Parkinson Disease or Parkinsonism, diagnosed between 2006 and 2011 in one of the participating hospitals. Screening for inclusion will be based on DBC codes;Inclusion criteria for controls:
Non-parkinsonian controls who presented between 2006 and 2011 in a neurology outpatient clinic of one of the participating hospitals, with neurological symptoms leading to a diagnosis coded in one of the following DBC codes: median nerve neuropathy (including Carpal Tunnel Syndrome), ulnaropathy, radicular syndrome / lumbar-thoracic disk herniation, lumbosacral pseudoradicular syndrome.
Controls will be selected on matching to cases based on hospital, age, and sex.
Exclusion criteria
All Parkinson or other Parkinsonism patients who are referred from another hospital or come for a second opinion will be excluded from participation. Also any potential participants under the age of 18 are excluded from participation.
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL21953.008.09 |