This study is dedicated to obtain accurate broadband (400 - 1830nm) diffuse reflectance spectra of human nerve tissue in vivo (which knowledge creates possibilities to design useful imaging devices).
ID
Source
Brief title
Condition
- Nervous system, skull and spine therapeutic procedures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Accurate broadband (400 - 1830nm) diffuse reflectance spectra of human nerve
tissue in vivo
Secondary outcome
Optimal probe positioning and comparison with camera images of tissue
Background summary
Complications arising from collateral damage to nerve tissue need to be
avoided. But within numerous procedures nerves are hard to visualize. If the
visualization of essential structures and planes could be enhanced with
information that so far remained invisible, than this could increase the safety
and speed of working (image guided surgery).
The *Van *t Hoff Program* of TNO works on several issues. One of these pertains
to special camera technologies to selectively enhance contrasts of specific
tissue types, like e.g. nerves. The principle is based upon recognition of the
optical spectral *fingerprint* (optical spectral analysis).
In order to recognize something, it is important to first learn about the
specific features of it. To precisely record the spectral fingerprint of nerve
tissue it is logical to choose a surgical procedure that requires the clear
exposure of nerves anyhow. Hence the choice to start such measurements during
surgical decompression of the median nerve to treat carpal tunnel syndrome
(CTS).
Study objective
This study is dedicated to obtain accurate broadband (400 - 1830nm) diffuse
reflectance spectra of human nerve tissue in vivo (which knowledge creates
possibilities to design useful imaging devices).
Study design
The study design is observational.
Study burden and risks
Minimal burden of maximum 10 minutes extra duration of surgery to perform the
spectral measurements.
No individual benefits involved.
Future benefit may be improved visualization of nerve tissue during surgery.
De Rondom 1
Eindhoven 5612 AP
NL
De Rondom 1
Eindhoven 5612 AP
NL
Listed location countries
Age
Inclusion criteria
Surgical release of carpal tunnel syndrome
Exclusion criteria
Pre- or peroperative use of medication with phototoxic side effects:
- Amiodaron (also Cordarone)
- Chloorpromazine (also Largactil)
- Hydrochloorthiazide
- Nalidixinezuur (also Nevigramon, Neggram of Wintomylon)
- Tetracycline (also Tetralysal, Panmycin, Brodspec, Terramycine
of Tetracap)
- Doxycycline (also Vibramycin)
- Naproxen (also Naproxenum, Naproxennatrium, Aleve, Anaprox, Naprosyne,
Femex, Naprocoat, Naprovite, Nycopren, Naprelan, Teva of Topgen)
- Piroxicam
- Thioridazine (also Mellaril, Novoridazine, Thioril)
- Voriconazol (also VFEND)
- Phenothiazines
- Dacarbazine
- Ketoprofen
- Lomefloxacin (also maxaquin) or other fluoroquinolones
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL42176.091.12 |