Understanding the cognitive disorders in patients who have woken up after a resuscitation and who were treated with a controlled temperature during the ICU treatment
ID
Source
Brief title
Condition
- Mental impairment disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Comparing scores on cognitive test scales between patients after cardiac arrest
treated with 33 or 36 degrees and patients after myocardial infarction.
Secondary outcome
Comparing the intensity of care for the carers between patients after cardiac
arrest and patients after myocardial infarction
Background summary
During cardiac arrest, brain damage occurs. This condition is called a
postanoxic encephalopathy. Clinically, this is reflected in a persistent coma,
but the patient may also wake up and recover well. In recent years it has
become clear that patients who made a "good" recovery suffer from cognitive
disorders. Which disturbance this and how they interfere with the daily
functioning of the patients is unknown.
Study objective
Understanding the cognitive disorders in patients who have woken up after a
resuscitation and who were treated with a controlled temperature during the ICU
treatment
Study design
international multicenter prospective study
Study burden and risks
There is no risk in this study. The entire cognitive test will take 2 hours
which can be a burden for the patient. This will be explained to the patient
who can at any time indicate that he / she wants to stop.
Meibergdreef 9
Amsterdam 1105 AZ
NL
Meibergdreef 9
Amsterdam 1105 AZ
NL
Listed location countries
Age
Inclusion criteria
1. TTM study patients who are alive at six-month follow-up and give consent to the cognitive sub-study
2. Informants (usually a relative or close friend/caregiver) of the patient above (1) who give consent to the cognitive sub-study
3. STEMI patients at the given centre, the sex-matched patient who best fits in age to the TMM patient above (1) with a similar date of infarct who gives consent to the cognitive sub-study
4. Informants (usually a relative or close friend/caregiver) of 3 above who give consent to participate.
Exclusion criteria
The same exclusion criteria as for the main TTM study with the addition that control patients should not have a history of cardiac arrest.
Exclusion criteria TTM study: Conscious patients, pregnancy, out-of-hospital cardiac arrest of presumed non-cardiac cause, cardiac arrest after arrival in hospital, known bleeding diathesis, suspected or confirmed acute intracranial bleeding, suspected or confirmed acute stroke, temperature on admission <30°C, unwitnessed asystole, persistent cardiogenic shock, known limitations in therapy, known disease making 180 day survival unlikely, known pre-arrest cerebral performance category 3 or 4, >240 minutes from ROSC to randomisation, no informed consent.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL40826.018.12 |