Since this cohort is at risk for many developmental problems, further follow-up on this cohort is warranted. We especially want to examine growth, pubertal development, and the neurocognitive- and behavioural development. Since we have many…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
bloeddruk, puberteitsontwikkeling, neurocognitieve ontwikkeling, gedrag
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Health development
• Height
• Weight
• Body mass index
• Head circumference
• Skin fold thickness: triceps, scapula, biceps, and suprailiac thickness
• Circumference of mid upper arm, waist and hip
• Pubertal development according to Tanner*s stadia, age of menarche
• Systolic and diastolic blood pressure (BP)
Neurocognitive- and behavioural development
• Intellectual development:
• Attention
• Executive functions
• Behaviour according to parents and child
Secondary outcome
Health questionnaire concerning the last 2 years
•Health problems; nature of problem; visit/treatment specialist; frequency of
visit
•Medication: sort medication; frequency
•Surgical treatment
•Disabilities
Family questionnaire
•Birth date parents
•Parental weight
•Parental height
•Country of birth
•Highest educational level
•Current employment
•Other members of the family
Educational level of the child
• National educational achievement test (CITO test); domain scores language
(taal), mathematics (rekenen-wiskunde), study abilities (studievaardigheden)
and geography (wereld orientate), a total score and a standard score
• School advice after CITO test
• Current level of education and grade
• Extra support at school (rugzakje)
Background summary
Hypertensive disorders of pregnancy, like preeclampsia and HELLP (hemolysis,
elevated liver enzymes and low platelet count) syndrome, are strongly
associated to intra uterine growth restriction (IUGR). Children born growth
restricted have an increase risk at several developmental domains, like
problems with growth, cognitive abilities and behavioural problems. Less is
known about the pubertal development, attention abilities and executive
functions (higher order functions).
In the Academic Medical Center Amsterdam (AMC) and the VU Medical Center
we have followed a cohort of children born to mothers that participated in the
PETRA (Pre-eclampsia Eclampsia TRial Amsterdam). These mothers had severe and
early onset hypertensive disorders of pregnancy. The majority of the children,
90%, had IUGR.
We have examined the PETRA children at age 3 months, 1 year, and 4.5
years. Follow-up at age 4.5 was performed in the outpatient clinic of the AMC.
We found a normal cognitive- motor- and behavioural development in 54% of the
participating children. There was catch-up growth, but the children were still
smaller and especially lighter compared to Dutch reference curves. We also
found that the degree of growth restriction at birth was strongly related to
all growth scores.
Study objective
Since this cohort is at risk for many developmental problems, further follow-up
on this cohort is warranted. We especially want to examine growth, pubertal
development, and the neurocognitive- and behavioural development. Since we have
many information of this cohort available, like for example the degree of IUGR,
our cohort is very suited to examine the consequences of hypertensive disorders
of pregnancy and IUGR on child development.
Objectives:
1. To assess the health of the PETRA cohort in puberty i.e. growth, fat
distribution, pubertal development, and blood pressure in rest and also in
response to a stressful event.
2. To assess the neurocognitive and behavioural development of the PETRA cohort
at puberty; IQ, attention, executive functioning, and behaviour.
3. To assess to relation between health and neurocognitive and behavioural
outcome of the PETRA cohort, both assessed at puberty.
3. To assess the relation of pubertic health, neurocognitive outcome and
behaviour of the PETRA cohort with pregnancy complications, and with growth and
development at age 1 year and 4.5 years.
5. To assess growth changes from 4.5 to 12 years in relation to neurocognitive
and behavioural changes from 4.5 to 12 years.
Study design
Design: Prospective cohort study
Duration: 3 years
Setting: The outpatient clinic of the Academic Medical Center Amsterdam
Study burden and risks
burden is negligible
Meibergdreef 9
Amsterdam 1105 az
NL
Meibergdreef 9
Amsterdam 1105 az
NL
Listed location countries
Age
Inclusion criteria
Study group: Children of the PETRA.
Control group: Age- and gender matched children born at term (>= 37 weeks gestational age) without growth restriction (>= 2500 grams) (either class mates or family).
Exclusion criteria
Study group: Only children from the PETRA are included.
Control group: Children born at a gestational age < 37 weeks, and or birth weight < 2500 grams, or children that are not age matched (> 1 year difference from corrected age of child in study group).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL42097.018.12 |