Compare VO2max between healthy children and children with asthma
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
conditieniveau
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
VO2max of healthy children compared to that of children with asthma
Secondary outcome
Correlation of VO2max and cortisol response (NL 37156.000.11).
Background summary
We recently demonstrated that children with asthma have significant lower
salivary cortisol levels compared to healthy prepubertal children]. It is
unknown whether this finding has clinical relevance. It remains unclear whether
the adrenal response is attenuated due to the chronic inflammation or due to
the lower endurance of the children with asthma. If the chronic inflammation is
the cause what is the effect of treatment with inhaled corticosteroids. In
addition, is the lower endurance the effect of their asthma or the effect of an
attenuated adrenal response?
Study objective
Compare VO2max between healthy children and children with asthma
Study design
Intervention study
Intervention
Maximal exercise test according to a standardized protocol.
During the exercise test oxygen uptake wil be measured with a breathanalyser
Pulse and oxygen saturation will be continously monitored.
Study burden and risks
We do not expect any additional risk for the children since they all play
community sports and are used to performing exercise.
Henri Dunantweg 2
Leeuwarden 8934 AD
NL
Henri Dunantweg 2
Leeuwarden 8934 AD
NL
Listed location countries
Age
Inclusion criteria
Children who participated in the NL 37156.000.1 study will be asked to participate.
The healthy children can be included if they are prepuberal and have no restrictions for performing an exercise test ;The children with astham can be included if they have stable asthma
and have not been treated with systemic steroids in the previous three months
and have no restrictions for performing an exercise test (and do not routinely use salbutamol before exercise)
Exclusion criteria
If informed consent is not given
if exercise tests are contraindicated due to the physical condition or asthma as judged by the paediatrician
if the child does not want to cooperate during the test or wants to stop the test
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL42187.000.12 |