Main: to examine how treatment response and non responder profiles relate to contemporary dichotomized forms and correlates of aggressive behaviour (i.e. pro active vs. reactive, cognitive distortions), location where the treatment is offered,…
ID
Source
Brief title
Condition
- Psychiatric disorders NEC
- Age related factors
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
We aim to compare the cognitive and behavioural profiles of treatment
responders, non-responders and drop outs in relation to genetic susceptibility
and across various contexts (schools, centre for Orthopsychiatry and
residential youth care agency). Our main question of enquiry here is: what
behavioural, cognitive and genetic profiles regarding aggressive behaviour and
correlates relating to aggressive behaviour can be found among responders and
non responders?
-It is hypothesised that non responder profiles shows lower levels of moral
reasoning and social skills, more proactive aggression, a higher sensitivity
towards reward, a more risk taking cognitive profile, and a higher genetic
susceptibility (specifically a higher activity of the MAO-A gene) and higher
levels of callous and or unemotional traits at baseline. However high levels of
impulsiveness could also be a trait of non responders.
Secondary outcome
Is ART effective in reducing aggressive behaviours (proactive or reactive)
among patients with a disorder of aggression regulation?
Are genetic risk factors for ADHD, CD and ODD as discovered by hypothesis-free
genetic studies, predictive for treatment response to ART?
It is hypothesized that after 10 weeks of follow up measurements on the
Modified Overt Aggression Scale (MOAS; Kay et al. 1988) the ART will prove to
be effective to reduce the frequency and severity of aggressive behaviours.
Background summary
The focus in efficacy studies of treatment of aggression problems mostly seems
to have been on recidivism rates of criminal acts in judicial terms (i.e.
convictions) and not so much on changes in aggressive behaviour. The
Aggression replacement training (ART) has been found to be effective in
numerous international studies. The efficacy of interventions for aggression
need to be examined in relation to specific types of aggressive behaviours
(i.e. reactive vs. proactive) and among early quitters, responders and
non-responders across various settings: schools, outpatient, inpatient clinics
and residential youth facilities. Furthermore, the genetic susceptibility also
plays an important role. Previous studies have shown for example that various
genotypes of the X-linked gene MAOA are differentially susceptible to treatment
and may influence long-term outcome. Additional genes of interest are the ones
currently being discovered in ongoing genome-wide analyses of ADHD, ODD and CD,
as these might also influence treatment outcome. In total, we expect to analyse
10-20 genes. The present study aims to answer efficacy questions from a real
world perspective by including a broad group of subjects, examining
pre-treatment predictors ofearly quitters, responders and non responders.
Study objective
Main: to examine how treatment response and non responder profiles relate to
contemporary dichotomized forms and correlates of aggressive behaviour (i.e.
pro active vs. reactive, cognitive distortions), location where the treatment
is offered, neuropsychological profiles (i.e. inhibition, sensitivity for
rewards and punishment or social information processing) and genetic
susceptibility.
Secondary: : to examine if the Aggression Replacement Training of Goldstein
(ART) can decrease (different types of) aggression among adolescents between 12
and 18 years old.
Study design
Observational multi-site treatment efficacy study among adolescents with severe
aggression problem.
Study burden and risks
Adolescents are indicated for ART treatment by their clinician. The nature and
extent of the burden is that we ask the adolescents and parents to participate
in our research and complete several questionnaires, neurocognitive tasks and
saliva. This will take 4 hours extra in total and they will get a compensation
of 50euros if they participate.
Furthermore there are no extra risks for the adolescents if they participate in
the research.
Reinier Postlaan 12
Nijmegen 6525 GC
NL
Reinier Postlaan 12
Nijmegen 6525 GC
NL
Listed location countries
Age
Inclusion criteria
-Full scale IQ at least 80;
PIQ <= 75 VIQ >= 80
-Minimal score on MOAS of 5 on both initial screenings
-Age lies between 12 and 18 years
-Minimal motivation among participant and family
-Reading level of Avi 6 or 7.
-Clinical diagnosis of ODD, CD based on DISC-IV
Exclusion criteria
- Previous ART (half year before )
-Psychotic condition
- Severe depression
-Severe substance dependency
- Suicidal
- Recently started medication (less than 2 weeks before ART training)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL41775.091.12 |