In the present study, we will investigate if a monocular visual field defect - due to primary open angle glaucoma - influences the anatomical integrity of the visual pathways.
ID
Source
Brief title
Condition
- Other condition
- Glaucoma and ocular hypertension
Synonym
Health condition
gezonde proefpersonen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
grey and white matter density, found by MRI signal
Secondary outcome
Location of changes in grey and white matter density.
Background summary
Previous research showed that opthalmological disorders, such as glaucoma and
macular degeneration are associated with a lowering of the volume of the grey
and white matter in the visual pathways in the brain. In these researches,
patients with binocular visual field defects due to the specific eye disease
were involved. However, in half of the patients with primary open angle
glaucoma, the visual field defect is monocular.
Study objective
In the present study, we will investigate if a monocular visual field defect -
due to primary open angle glaucoma - influences the anatomical integrity of the
visual pathways.
Study design
With an MRI scanner, we will obtain images of the brain. With statistical
software, the grey and white matter density in subjects with glaucoma and in
healthy control subjects will be compared.
Study burden and risks
MRI is a non-invasive method for imaging and studying the brain. Subjects are
exposed to an magnetic field of 3 Tesla, and altered magnetgradients. The
applied fieldquantities have been applied for routine MRI research for a long
time. So far, there have no adverse effects been reported.
Hanzeplein 1
Groningen 9713 GZ
NL
Hanzeplein 1
Groningen 9713 GZ
NL
Listed location countries
Age
Inclusion criteria
- age over 18 years;Patients:
- monocular blindness; or
- monocular visual field defect due to glaucoma;Controls:
- normal vision
- healthy
Exclusion criteria
General:
- presence of metal implants
- non-removable piercings and tattoos
- claustrofobia
- epilepsia
- (presumable) pregnancy;Specific for patients:
- other ophtalmological or neurological disorders
- usage of drugs or medicine other than for the treatment of glaucoma;Specific for healthy controls:
- usage of medicine or drugs that could influence the examination
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL41425.042.12 |