This study evaluates if there is a difference in platelet function during and following the use of minimal ECC compared with conventional ECC in coronary artery bypass grafting (CABG) analysed with tromboelastography en multiple electrode aggrometry…
ID
Source
Brief title
Condition
- Platelet disorders
- Coronary artery disorders
- Vascular therapeutic procedures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Results tromboelastography and multiple electrode aggregometry
Secondary outcome
perioperative blood loss
blood loss every hour after PACU/IC admission for 4 hours
total blood loss 24 hours after CABG
total amount of transfused packed cells perioperative
total amount of transfused packed cells 24 hours after CABG
total amount of transfused platelets perioperative
total amount of transfused platelets 24 hours after CABG
total amount of transfused fresh frozen plasma perioperative
total amount of transfused fresh frozen plasma 24 hours after CABG
Background summary
The introduction of cardiopulmonary bypass (CPB) in the 1950s has allowed
development in heart surgery. Cardiopulmonary bypass is a safe and method with
low mortality rates. Nevertheless morbidity in cardiopulmonary bypass is
significant. Cardiopulmonary bypass leads to hemodilution, complement and white
cell activation with systemic inflammatory response, platelet activation, the
need for intensive anticoagulation, systemic organ dysfunction and the frequent
need for blood and blood products to control postbypass bleeding or blood loss.
The pathofysiology is not fully elucidated but has been related to blood
contact with foreign surface. Minimal-ECC circuits minimise foreign
surface-blood interaction and are heparinized from tip to tip. The tubing legth
has been shortened to decrease crystalloid prime. Cardiotomy suction is
minimised. An active air-removal device is added to the closed circuit. The use
of minimal ECC has already shown a significant reduction of the systemic
inflammatory reaction and less perioperative transfusion of blood products.
Study objective
This study evaluates if there is a difference in platelet function during and
following the use of minimal ECC compared with conventional ECC in coronary
artery bypass grafting (CABG) analysed with tromboelastography en multiple
electrode aggrometry.
Study design
Monocenter, prospective, observational, pilot study
Study burden and risks
None, an extra 46 ml of blood will be taken via an already inserted arterial
line according to the standard protocol for coronary artery bypass surgery
Michelangelolaan 2
Eindhoven 5623 EJ
NL
Michelangelolaan 2
Eindhoven 5623 EJ
NL
Listed location countries
Age
Inclusion criteria
- patients undergoing non emergency coronary artery bypass grafting using conventional extracorporeal circulation or minimal extracorporeal circulation
- 18 years and older
- left ventricle function >50%
Exclusion criteria
- emergency setting
- platelet function disorders before surgery
- thrombocytopenia
- renal insufficiency
- use of clopidogrel shorter than 5 days before surgery
- chronic alcohol abuse
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL40546.060.12 |