To study the effect of compression stockings during supine and head up tilt on cardiac stroke volume as a reflection of the changes in central blood volume.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
hemodynamic
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Stroke volume, cardiac output, heart rate, arterial blood pressure
Secondary outcome
Tissue oxygen saturation (StO2) and perfusion index (PI)
Background summary
The head up tilt from supine position is a commonly used maneuver to induce an
acute reduction in central blood volume. The reduction of preload leads to a
decrease in stroke volume and an increase in heart rate in order to maintain
cardiac output and arterial blood pressure. These central hemodynamic
alterations are accompanied by vasoconstriction, leading to decreased
perfusion of the peripheral circulation. Our hypothesis is that the
application of compression stockings on the lower extremities prevents the loss
of central blood volume during head up tilt and thereby will help maintain
central and peripheral perfusion during this maneuver.
Study objective
To study the effect of compression stockings during supine and head up tilt on
cardiac stroke volume as a reflection of the changes in central blood volume.
Study design
Intervention study
Intervention
Volunteers will wear compression stockings on both legs, which will be inflated
prior to the head up tilt maneuver from supine position. Stockings will be
inflated for 3 minutes during supine and head up tilt to the pressures of 50
cmH2O. Central hemodynamic measurements will be performed non-invasively with
Finapres®. Peripheral perfusion will be measured non-invasively with near
infrared spectroscopy (NIRS) and finger plethysmography, applied to the thenar
and index finger, respectively.
Study burden and risks
We will apply a pressure of 50 cmH2Oto inflate the compression stockings. This
pressure has been proven safe, not painful and not to induce ischemia. Since
all techniques and measurements are non-invasive , the participating
volunteers will not be exposed to additional risks.
's-Gravendijkwal 230
Rotterdam 3015CE
NL
's-Gravendijkwal 230
Rotterdam 3015CE
NL
Listed location countries
Age
Inclusion criteria
Healthy subjects
Exclusion criteria
- Subjects will be excluded if they are taking cardio-active or neuro-active medications or if they have a history of syncope or orthostatic intolerance.
- Wounds on the lower leg
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL40523.078.12 |