To establish compare vessel wall dimensions and inflammation in AS with healthy matched control subjects with MRI and PET-FDG
ID
Source
Brief title
Condition
- Coronary artery disorders
- Autoimmune disorders
- Arteriosclerosis, stenosis, vascular insufficiency and necrosis
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Difference in TBR between AS patients and controls
Secondary outcome
-Carotid artery dimensions
Background summary
Ankylosing Spondylitis (AS) is a systemic inflammatory disease characterized by
axial joint involvement, sacroiliitis and various extra-articular
manifestations. It has been suggested that atherogenesis may be enhanced in AS
as an increased cardiovascular mortality has been reported. The inflammatory
process in the vessel walls, leading to atherosclerosis, may be amplified by
the presence of systemic inflammation due to AS. FDG-PET is a novel imaging
technique to quantify vessel wall inflammation.
Study objective
To establish compare vessel wall dimensions and inflammation in AS with healthy
matched control subjects with MRI and PET-FDG
Study design
The study objective will be addressed by a cross-sectional study.
Study burden and risks
Patients will visit the department for 6 hours. The withdrawal of blood and
infusion of FDG contrast may cause light reactions or a blue spot. No extra
discomfort is expected. A moderate radiationload is expected as a consequence
of performing the PET-CT scan.
Meibergdreef 9
Amsterdam 1105AZ
NL
Meibergdreef 9
Amsterdam 1105AZ
NL
Listed location countries
Age
Inclusion criteria
Subjects with AS
-Age: above18 years
-Diagnosis of AS + disease duration since start of first symptoms for a period of more than 3 years.
Exclusion criteria
Subjects may not enter this study if they meet the following criteria
-BMI > 30.
-history of diabetes mellitus/insulin use
-hypertension/use of blood pressure lowering medication
-use of statins
-history of cardiovascular events
-proven or suspected bacterial infections.
-use of anti-inflammatory medication from group "biologicals"
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL40662.018.12 |