Influence of Injection time of DCE-MRI for prostate cancer patients with consistent kinetic parameters.
ID
Source
Brief title
Condition
- Reproductive neoplasms male malignant and unspecified
- Prostatic disorders (excl infections and inflammations)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Establish the influence of injection time of kinetic tracer parameters,
determined with Dynamic Constrast-Enhanced MRI of the prostate.
Secondary outcome
none
Background summary
DCE-MRI technique can be used to characterize the perfusion of
microvascularisature in tissue. Because tumor growth is associated with
neovascularization, this technique is valuable for the detection of tumors. To
provide accurate detection of small tumors and a precise delineation of a tumor
volume. Therefore it is important to determine the influence of injection time
with the use of consistent TKA parameters.
Study objective
Influence of Injection time of DCE-MRI for prostate cancer patients with
consistent kinetic parameters.
Study design
Patient wil uindergo the standard MRI exam a second time before treatment of
prostate cancer
Study burden and risks
Patients will undergo the standard MRI exam a second time. In the standard exam
15 ml of the contrast agent Dotarem (Gadoteric acid , concentration 0.5M) is
administrated intravenenously. No adverse effects are known of the
administration of a second dose the next week after the regular exam. The
repeat of the MRI exam causes a negligible risk for the patient.
Plesmanlaan 121
AMSTERDAM 1066CX
NL
Plesmanlaan 121
AMSTERDAM 1066CX
NL
Listed location countries
Age
Inclusion criteria
biopsy proven prostate cancer
able to undergo MRI
Exclusion criteria
• • Contra-indications for a MRI exam according to the standard protocol for the screening of patients with prostate cancer.
• GFR < 30 ml/min/1.73 m²
• Treatment of prostate cancer prior to the MRI exams.
• Prior hormonal therapy
• Prior trans-urethral resection (TURP)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL40706.031.12 |