To examine the effect of BCG as a booster vaccine on salmonella typhi Vi polysaccharide vaccination
ID
Source
Brief title
Condition
- Bacterial infectious disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The following parameters are compared between two groups: cytokine production
and antibody titers against salmonella typhi Vi antigen on different time
points after vaccination.
Secondary outcome
Gene polymorphisms are analyzed and correlated with innate immunity function
Background summary
The live attenuated Bacillus Calmette-Guerin (BCG) vaccine protects against
Mycobacterium tuberculosis and leprosy. It is also used as booster vaccine to
improve the immunogenicity against other vaccines. We hypothesize that BCG
vaccination 14 days before salmonella typhi Vi polysaccharide vaccine improves
the effect of this vaccine.
Study objective
To examine the effect of BCG as a booster vaccine on salmonella typhi Vi
polysaccharide vaccination
Study design
observational study between 2 groups (with or without BCG vaccination)
Study burden and risks
There is no direct benefit to the participating subjects but it is expected
that these results will potentially lead to a novel approach to vaccine
strategies for travelers. The risks are negligible, the only risk involving
local hematoma formation at the site of the blood drawing. This will be
minimized by the blood collection by experienced persones.
geert grooteplein 8
6525GA nijmegen
NL
geert grooteplein 8
6525GA nijmegen
NL
Listed location countries
Age
Inclusion criteria
Healthy medical students who are scheduled to go on clinical rotation in developing countries and need to be vaccinated with BCG and typhoid fever vaccine
Exclusion criteria
Subjects should not come from a Salmonella typhi endemic country and are not allowed to use any medication except oral anticonception drugs.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL39957.091.12 |