Primary Objectives:1: Gain insight in the way arm function changes during the natural course of DMD through 3D movement analysis, surface electromyography and ambulant activity monitoring.2: Investigate if a newly developed exoskeleton is able to…
ID
Source
Brief title
Condition
- Muscle disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameters are: maximal sEMG amplitude during movements as
percentage of EMG amplitude in Maximum Voluntary Contraction, active range of
motion and activity level during a longer period of time.
Secondary outcome
Secondary study parameters are: a questionnaire on medical history, drug use
and activity level, passive range of motion, absolute muscle force, fatigue,
pain and quantitative ultrasound for measuring muscle volume and muscle
quality
Background summary
Due to progression of the disease a boy with Duchenne Muscular Dystrophy (DMD)
will lose gradually his arm function after he gets wheelchair confined. A
possible solution to compensate the loss of arm function is the development of
an exoskeleton. To give input to the technical engineers of such an
exoskeleton, more insight in the patterns of deterioration is needed.
A pilot study, using 3D movement analysis combined with surface
electromyography (sEMG) has proven to be a new effective way of studying the
course of disease. Therefore this method is used to determine the course of
deterioration in a larger group of boys with DMD.
Study objective
Primary Objectives:
1: Gain insight in the way arm function changes during the natural course of
DMD through 3D movement analysis, surface electromyography and ambulant
activity monitoring.
2: Investigate if a newly developed exoskeleton is able to support the arm
functions and activities in boys with DMD effectively.
3: To examine the possibility of activity classification of arm movements of
people with DMD with the use of ambulatory motion monitoring.
Study design
Explorative case control study
Study burden and risks
The burden and risks associated with participation are very small. The
movements that are measured are movements that are also performed in daily
living and the movements will not be forced. Furthermore, the measurement
protocol is not invasive.
Reinier postlaan 2
Nijmegen 6525 GC
NL
Reinier postlaan 2
Nijmegen 6525 GC
NL
Listed location countries
Age
Inclusion criteria
DNA established diagnosis of DMD
Brooke scale 1-5
Exclusion criteria
Other disabling diseases influencing upper extremity function
Boys <= six years old
Surgical scoliosis correction
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL39126.091.12 |