We propose to perform a pilot study to examine the feasibility of studying the triangular association between: 1) amino acid metabolism (influenced by, amongst other factors, diet composition [e.g. energy intake, macronutrient intake, individual…
ID
Source
Brief title
Condition
- Malabsorption conditions
- Appetite and general nutritional disorders
- Gastrointestinal therapeutic procedures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Dietary intake will be assessed by a trained research dietician by three 24h
recalls (one in-person and two by telephone) using the multiple pass technique.
Mean daily energy intake, protein intake and carbohydrate intake will be
calculated using the Dutch Food Composition Database 2011. Depression/anxiety
will be assessed using the Hospital anxiety and depression scale (HADS). Amino
acid profiling will be done in blood plasma by high performance liquid
chromatography (HPLC)/fluorescence. Characteristics of patients, including
weight loss, will be obtained from medical records.
Secondary outcome
not applicable
Background summary
The mechanisms that make losing weight and maintaining weight loss difficult
are largely unknown. Bariatric surgery is an effective treatment option for
morbid or complicated obesity. However, the response to treatment varies and a
rebound phenomenon after initial weight loss is common. Amino acids are
precursors of a number of neurotransmitters involved in the pathogenesis of
psychiatric illness and likely influence appetite. We hypothesize that by
influencing neurotransmitter metabolism a relative deficiency of specific amino
acids after bariatric surgery influences appetite and/or results in a poorer
psychological status that hampers weight loss or results in a rebound
phenomenon.
Study objective
We propose to perform a pilot study to examine the feasibility of studying the
triangular association between: 1) amino acid metabolism (influenced by,
amongst other factors, diet composition [e.g. energy intake, macronutrient
intake, individual amino acid intake], insulin and systemic inflammation); 2)
mood disorders (depression/anxiety); and 3) weight loss in subjects undergoing
gastric bypass surgery.
Study design
Cross-sectional, observational study
Study burden and risks
The burden on patients because of participation in this study are minimal and
risks are absent. Usual care for subjects will be maintained. Patients will be
approached to participate in the study during routine visits. Assessment of
dietary intake will be obtained by means of a 24 hour recall. During this
recall - which usually takes about 30-45 minutes the first time - information
is obtained about a patients* food intake during the preceding 24 hours. In
addition, a short depression questionnaire (the HADS, consisting of 14 closed
questions, will take 10 minutes) will be obtained. An extra blood sample (4 ml)
will be obtained during regular blood withdrawal which is part of usual care.
In the week following the hospital visit, patients will be approached for two
additional 24 hour recalls by telephone (20-30 minutes).
Louwesweg 6
1066 EC Amsterdam
NL
Louwesweg 6
1066 EC Amsterdam
NL
Listed location countries
Age
Inclusion criteria
Patients who underwent Roux-en-Y gastric bypass surgery at Slotervaart Hospital, Amsterdam
Exclusion criteria
Patients who receive parenteral feeding or use protein/energy supplements
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL39396.048.12 |