To validate and determine the accuracy of an inverse model for determining motor unit properties based on high-density surface EMG measurements from biceps brachii and tibialis anterior muscles.
ID
Source
Brief title
Condition
- Muscle disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Study parameters are: muscle fibre orientation, motor endplate zone, muscle
fibre conduction velocity, muscle fibre length, and motor unit size as
determined by various techniques.
Secondary outcome
n.a.
Background summary
Electromyography (EMG) measures the electrical activity of motor units which
are the smallest controllable unit of the neuromuscular system. High-density
surface electromyography uses a large number of small electrodes to cover the
muscle and allows to determine both temporal and spatial information on
individual motor units such as main muscle fibre orientation, muscle fibre
conduction velocity, and motor endplate zone. So far, there is no validated
method for extracting these motor unit properties. This especially concerns
muscles with a pinnate muscle fibre structure.
This study aims at validating an inverse model for determining motor unit
properties using experimentally obtained data from two different muscles
(biceps brachii and tibialis anterior). For this purpose, high-density surface
EMG is recorded with different electrode grid orientations. Intra-muscular fine
wire EMG is simultaneously recorded. In this manner evaluation and tracing of
identical motor unit potentials is controlled while the surface electrode grid
is relocated. The motor unit variables extracted by the inverse model are
compared to corresponding data obtained by independent methods (intramuscular
fine wire and scanning EMG and muscle ultrasound). In addition, electrode grid
displacement and re-orientation is monitored by metric and angular registration
of electrode grid borders on landmarks and reference lines drawn on the skin.
Study objective
To validate and determine the accuracy of an inverse model for determining
motor unit properties based on high-density surface EMG measurements from
biceps brachii and tibialis anterior muscles.
Study design
Observational study of explorative nature
Study burden and risks
Two muscles are examined using muscle ultrasound, fine wire EMG, scanning EMG
and high-density surface EMG. The techniques used are well established and
cause no risk to the subject. The fine wire electrodes will only cause
discomfort during insertion which is comparable with a muscular injection. The
wires are hardly noticed after the needle is retracted. The scanning EMG needle
is a standard EMG needle which causes some discomfort during the scanning
measurement which takes about two minutes. The total time required for the
experiment is estimated to be 2 hours. The participating subject will receive
50 euro as compensation for time and discomfort.
Postbus 9101
6500 HB Nijmegen
NL
Postbus 9101
6500 HB Nijmegen
NL
Listed location countries
Age
Inclusion criteria
Healthy volunteers between 18 and 60 yrs
Exclusion criteria
neuromuscular disorder
blood clotting disorder
Obese subjects are unsuited as the surface EMG signals are strongly attenuated with distance.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL39681.091.12 |