To evaluate associations between specific characteristics of DA GMs around 3 months CA and daily function at 8 years.
ID
Source
Brief title
Condition
- Neurological disorders congenital
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Motor skills domain of the Vineland Adaptive Behavior Scale (VABS)
Secondary outcome
- VABS domains: communication, daily life activities, socialization
- Developmental Coordination Disorder Questionnaire (DCD-Q)
- Child Behavior Check List (CBCL)
- additional information on specific learning disorders, need of special
school, psychiatric diagnoses.
In addition information is collected on
- parental coping behaviour by means of the Utrechtse Coping Lijst
- parental education and profession and family composition
- interventions which the child received
- medical history
Background summary
Definitely abnormal general movements (GMs) around 3 months corrected age (CA)
indicate a high risk for developmental disorders, such as cerebral palsy (CP)
or behavioural disorders. We recently reported that specific characteristics of
definitely abnormal (DA) GMs around 3 months CA, such as the absence of
*fidgety* movements and the presence of stiff movements, improve prediction of
outcome at 18 months of age (Hamer et al. 2011). As the brain continues to
develop throughout childhood, associations between early risk factors and later
outcome may change with age. This means that associations between risk factors
and developmental outcome at early age may disappear when the child grows older
(children *grow out* of their problem). But also the reverse may occur:
associations between early risk factors and developmental outcome may get
stronger as dysfunctions may emerge when the brain develops new functions. The
latter occurs often in high risk infants, such as infants born preterm.
Therefore the present study aims to determine whether specific movement
characteristics of general movements also improve prediction for impaired daily
function at school age.
Study objective
To evaluate associations between specific characteristics of DA GMs around 3
months CA and daily function at 8 years.
Study design
Re-assessment of participants of a randomized controlled trial (RCT) on the
effect of physiotherapeutic intervention in infancy (VIP-project). The
participants of the VIP-project were included on the basis of presence of DA
GMs around 3 months CA. The RCT indicated that intervention did not affect
outcome at 18 months, which allows for pooling of the two groups to study
associations between early motor characteristics and outcome at 8 years (in
analogy to the previous study in which we demonstrated associations between
characteristics of DA GMs and developmental outcome at 18 months; Hamer et al.
2011).
Study burden and risks
There are no risks associated with participation. Costs of the study are a
limited time investment of parents and investigators.
Hanzeplein 1
Groningen 9713 GZ
NL
Hanzeplein 1
Groningen 9713 GZ
NL
Listed location countries
Age
Inclusion criteria
Definitely abnormal GMs at 3 months corrected age, participant in the VIP-project (see protocol sections 3 and 4).
Exclusion criteria
In the VIP project children with severe congenital anomalies, such as serious congenital heart disorders, and infants whose caregivers had an inappropriate understanding of the Dutch language were excluded from the study.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| Other | ISRTCN52740878 |
| CCMO | NL39954.042.12 |