The goal of the current study is to investigate the functional relevance of higher order cortical areas for cognitive task execution involving inhibitory and emotional processes by means of TMS.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
In many scientific publication it is stressed that TMS can lead to a much better understanding of brain function. This is because it allows revealing causal relationships. Our research will convey deeper insights into the neuronal mechanisms underlying inhibitory processes and to which extent the dysfunction of such processes can lead to dysfunctional emotional processing.
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
TMS-induced behavioral changes assessed via reaction times (measured by button
presses), and error rates (computed from the percentages of correct and false
responses).
Secondary outcome
not applicable
Background summary
TMS is able to reveal causal patterns of brain function and human behaviour.
Transcranial magnetic stimulation (TMS) will be used to disrupt neuronal
activity in well-defined brain areas prior to the execution of various tasks
requiring inhibitory and emotional processing. Our main interest is the
interaction between the classical higher-order executive frontoparietal areas,
response inhibition and emotions.
Study objective
The goal of the current study is to investigate the functional relevance of
higher order cortical areas for cognitive task execution involving inhibitory
and emotional processes by means of TMS.
Study design
The participant will have to fill in a screening questionnaire. This will take
approximately 20 minutes and will happen in the first session. Thereafter the
medical supervisor will decide on whether the participant is allowed to take
part in the experimental sessions. If this is the case, the participant will
come back for 5 experimental sessions. In three of the sessions, the
participant will receive real TMS, on three brain sites before performing a
task requiring inhibitory and/ or emotional processing. In the other sessions,
the participant will receive placebo (Sham) TMS or TMS on a task-irrelevant
control site before performing the same task which serves as a control
condition. Each session will take approximately 1.5 hours, including 15 minutes
preparation time.
Intervention
Transcranial Magnetic Stimulation (TMS) prior to task execution.
Study burden and risks
The total time amount a participant has to invest in the experiment does not
exceed 7.5 hours. In the beginning a medical screening will take place.
Afterwards 5 sessions of around 1.5 hours each will take place. During each of
these sessions maximally 1750 TMS pulses will be applied.
Postbus 616 616
Maastricht 6200 MD
NL
Postbus 616 616
Maastricht 6200 MD
NL
Listed location countries
Age
Inclusion criteria
Healthy vonlunteers, aged 18-45 years.
Exclusion criteria
(Family)background of mental health issues or epilepsy, and metal or medical implants in the body. You can find a detailed overview of all exclusion criteria in the attached TMS screening questionnaire. The medically responsible physician Dr. C. J. van Leeuwen will check whether or not a candidate is suited for participantion in the experiment.
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL39572.068.12 |