The primary goal is to investigate whether there are deficits in the response inhibition and performance monitoring in cannabis dependent patients on both a behavioral and an electrophyisiological level. The secondary goals are to investigate…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
middelen afhankelijkheid
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameters are ERP modulations in response to the Go/NoGo and
Eriksen Flanker Task. The end of this study will be reached when 60
participants are included and tested successfully.
Secondary outcome
To investigate whether there is a correlation with the amount and years of use
on the one hand and the degree of errors and diminished neural correlates on
the other hand. To investigate whether there is a correlation with the amount
and years of use on the one hand and the degree of response inhibition on the
other hand.
Background summary
Two important aspects of the cognitive control system in contemporary addiction
models are inhibitory control and performance monitoring. The suggestion is
made that impaired response inhibition is associated with difficulties to
resist the use of a substance and that substance dependent patients are often
insensitive to future negative consequences. Deficits in response inhibition
and performance monitoring have been found in several addiction populations but
have not yet been confirmed in cannabis dependent patients.
Study objective
The primary goal is to investigate whether there are deficits in the response
inhibition and performance monitoring in cannabis dependent patients on both a
behavioral and an electrophyisiological level. The secondary goals are to
investigate whether there is a correlation with the amount and years of use on
the one hand and the degree of errors in perfomracne monitoring and response
inhibition on the other hand.
Study design
Participants will perform two tasks. First, participants will perform a Go/NoGo
Task utilizing ERP measurements to examine the electrophysiological correlates
of response inhibition. Second, participants will perform an Eriksen Flanker
Task, utilizing ERP measurements to examine the electrophysiological correlates
of performance monitoring. In both tasks, cannabis dependent patients will be
compared with nicotine dependent controls. Participants need to be abstinent of
cannabis for 24 hours and abstinent of nicotine for 2 hours. Both experiments
will take place in the Erasmus Behavioral Lab of the Erasmus University in
Rotterdam.
Study burden and risks
EEG is a safe, painless and non-invasive method for measuring brain activity.
Since participants have to sit relatively still, effort will be made to make
the test session as comfortable as possible (comfortable chair, pillows, breaks
between blocks of trials).
Postbus 1738
3000 DR Rotterdam
NL
Postbus 1738
3000 DR Rotterdam
NL
Listed location countries
Age
Inclusion criteria
1) Signed informed consent
2) Age between 18 and 25 years old
3) Normal or corrected-to-normal vision (is able to read presented text in EEG task easily)
4) Being a sigaterette smoker (at least 3 sigarettes in a week);Additional criterium for patient-group
5) Meeting the DSM-IV criteria of cannabis dependence
Exclusion criteria
1) History of significant medical illness and/or psychiatric disorders
2) Psychotropic medication
3) Alcohol use within 24 hours of the day of testing
4) Nicotine use within 3 hours of the experiment;Patient group
5) Meeting the DSM-lV criteria for dependence on other substances than nicotine or cannabis;Control group
5) Meeting the DSM-lV criteria for dependence on other substances than nicotine
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL39635.078.12 |