This project aims to investigate the role of sleep on memory processing in PTSD. The primary aim of the study is to assess the effects of sleep architecture on emotional memory processing and neurocognitive functioning in subjects with and without…
ID
Source
Brief title
Condition
- Anxiety disorders and symptoms
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary study parameters are memory for emotional and neutral film
fragments, physiological signals during film fragments (ECG, respiratory
effort, galvanic skin response), and emotional responses during the film
fragments. Further main study parameters are neurocognitive functions
(attention, planning, declarative memory).
Secondary outcome
Correlates of sleep architecture will also be investigated in stress hormones.
For the patient group, predictive effects of sleep architecture and memory
processes on response to treatment will be studied.
Background summary
Posttraumatic stress disorder (PTSD) is a mental health problem with a high
prevalence in the general population; 8% of the population is diagnosed with
this disorder during their lives. Previous sleep studies in healthy subjects
suggest the occurrence of adaptive changes in sleep architecture after
emotional experiences, which likely play a role in emotional housekeeping and
attenuation of the emotional responses towards negative emotional experiences.
Sleep thus seems important for emotional recovery from traumatic experiences
and PTSD.
Study objective
This project aims to investigate the role of sleep on memory processing in
PTSD. The primary aim of the study is to assess the effects of sleep
architecture on emotional memory processing and neurocognitive functioning in
subjects with and without PTSD. A secondary objective of the study is to assess
the relationship between sleep architecture and efficacy of PTSD treatment for
the patient group.
Study design
Controlled patient study with two experimental groups and a control group.
Effects of sleep architecture will be assessed in emotional and neutral memory
tasks, performed before and after sleep. Sleep architecture will be assessed by
performing nightly polysomnography (PSG).
Study burden and risks
The burden and risks associated with participation in this study are
reasonable. Participants can follow the regular clinical procedure for
assessment and treatment with one extra week between intake and start of
treatment. The confrontation with emotional film material and/or being
interviewed about the symptoms can be an emotional burden. The proposed
procedures are not invasive.
Meibergdreef 5
1105 AZ Amsterdam
NL
Meibergdreef 5
1105 AZ Amsterdam
NL
Listed location countries
Age
Inclusion criteria
Inclusion criteria for the PTSD group are:
1) Meeting diagnostic criteria for PTSD according to Clinician-Administered PTSD Scale (CAPS) with a total score of at least 50;
2) Age between 18 and 65;
3) Eligible for trauma-focused psychotherapy;
4) Written informed consent.;Inclusion criteria for the trauma-exposed control group are:
1) Having experienced at least one traumatic event as defined by DSM-IV in the absence of diagnostic criteria for PTSD according to CAPS and criteria for severe MDD according to MINI-PLUS clinical interview;
2) Age between 18 and 65;
3) Written informed consent.;Inclusion criteria for the non-trauma exposed control group are:
1) Having experienced no traumatic events as defined by DSM-IV and absence of diagnostic criteria for PTSD according to CAPS and criteria for severe MDD according to MINI-PLUS clinical interview;
2) Age between 18 and 65;
3) Written informed consent.
Exclusion criteria
Exclusion criteria for all groups are:
1) Acute suicidality;
2) Presence of a psychotic disorder, bipolar disorder, depression with psychotic features, or excessive substance related disorder over the past 3 months;
3) Prior history of neurological or sleep disorders, or an atypical sleep pattern with less than 6 hours sleep per night, or sleep time outside the window of 10 PM till 10 AM (for the PTSD group: neurological or sleep disorders prior to onset of PTSD).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL38987.018.11 |