The aim of this study is to determine whether Staphylococcus aureus colonizes the human throat and the perineal area independent of the nose.
ID
Source
Brief title
Condition
- Bacterial infectious disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
- In the first phase of the study the endpoint is to define the natural S.
aureus carriage state of the nose, the throat and the perineal area over a
follow-up period of 12 weeks among a cohort of volunteers. At the end of this
phase those volunteers who, considering the definition (chapter 6.2 of
protocol), are categorized as non-carriers for S. aureus will stop
participating. The remaining volunteers will be included in the second phase of
the study.
- In the second phase the effect of nasal eradication of S. aureus (using nasal
mupirocin) on nasal, throat and perineal carriage with S. aureus will be
determined.
Secondary outcome
not applicable
Background summary
Carriage of S. aureus on extra nasal body sites is less well studied than that
of the vestibulum nasi. Yet there are indications that extranasal culturing, in
particular of the throat and perineal area, is at least of similar importance
as nasal culturing alone to determine carriage rates. The question remains
whether throat or perineal without nasal colonization with S. aureus occurs,
and if so what is the incidence and what are the implications on decolonization
strategies.
Study objective
The aim of this study is to determine whether Staphylococcus aureus colonizes
the human throat and the perineal area independent of the nose.
Study design
We propose a two-phase prospective experimental follow-up study.
Intervention
Mupirocin treatment.
Study burden and risks
Volunteers will have no benefits by participation in this study. The results
obtained by this study might have a profound impact on the application of
decolonization strategies for MRSA/S. aureus in populations at risk.
Noorderhavenkade 165 A 2
3039 RS Rotterdam
NL
Noorderhavenkade 165 A 2
3039 RS Rotterdam
NL
Listed location countries
Age
Inclusion criteria
Volunteers above the age of 18 years.
Exclusion criteria
Antibiotic usage in the last 4 weeks.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL40156.078.12 |