The primary objective is to study differences in global lung aeration as defined by the center of ventilation before and during use of neuromuscular blockade. The secondary objective is to study differences in regional lung aeration before and…
ID
Source
Brief title
Condition
- Lower respiratory tract disorders (excl obstruction and infection)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Differences in global lung aeration as defined by the center of ventilation
before and during use of neuromuscular blockade
Secondary outcome
Differences in regional lung aeration before and during use of neuromuscular
blockade
Background summary
Neuromuscular blockade is often used to facilitate mechanical
ventilation in children. However, the use of sustained neuromuscular blockade
impairs spontaneous breathing. In mechanically ventilated adult patients,
there is cephalid shift of the diaphragm in the dependent lung zones
leading to alveolar collapse and hypoxaemia. This has not been studied in
critically ill children.
Study objective
The primary objective is to study differences in global lung aeration as
defined by the center of ventilation before and during use of neuromuscular
blockade. The secondary objective is to study differences in regional lung
aeration before and during use of neuromuscular blockade.
Study design
Prospective observational study without invasive measurements.
Study burden and risks
The are no risks associated with this study. Blood samples are drawn from
the already present indwelling arterial catheter. For the EIT
measurements 16 electrodes are placed circumferentially around the
chest of the patient. This is comparable with the use of electrodes for
routine continuous ECG measurement.
Hanzeplein 1
Groningen 9713 BZ
NL
Hanzeplein 1
Groningen 9713 BZ
NL
Listed location countries
Age
Inclusion criteria
• Age between 0 and 12 years
• Need for neuromuscular blockade defined by the attending physician
• Presence of acute lung injury
• weight >= 3 kg
Exclusion criteria
• No need for neuromuscular blockade
• No acute lung injury
• admitted to the neonatal intensive care unit
• premature birth with gestational age corrected for post-conceptional age less than 40 weeks
• congenital or acquired neuromuscular disorders
• severe traumatic brain injury (i.e. Glasgow Coma Scale < 8)
• congenital or acquired paralysis of the diaphragm
• uncorrected congenital heart disorder
• severe pulmonary hypertension
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL39989.042.12 |