The objective of this study is to assess changes in lung aeration and lung perfusion in patients who will undergo electrocardioversion.
ID
Source
Brief title
Condition
- Cardiac arrhythmias
- Lower respiratory tract disorders (excl obstruction and infection)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study endpoint is the change in regional lung aeration before and
after ECV, assessed by EIT.
Secondary outcome
Secondary study endpoint is the change in regional lung perfusion before and
after ECV, assessed by EIT.
Background summary
Short-term sedation is mandatory for electrocardioversion (ECV) for atrial
fibrillation. Sedation, however, lowers the functional residual capacity and
increases the risk of lung atelectasis due to hypoventilation, rendering
patients prone to atelectasis-related pulmonary problems.
In atrial fibrillation, cardiac output is less than optimal and this could
decrease lung perfusion. Stroke volume improves when sinus rythm is restored
after ECV, which could lead to an improvement in lung perfusion.
Electrical Impedance tomography (EIT) is a real-time, non-invasive, bed-side,
radiation-free continuous imaging technique able to detect changes of regional
lung aeration and -perfusion.
Study objective
The objective of this study is to assess changes in lung aeration and lung
perfusion in patients who will undergo electrocardioversion.
Study design
Observational study in patients under light sedation for electrocardioversion
for atrial fibrillation.
Study burden and risks
In this observational study there are no risks involved for participating
patients. Patient burden is minimal to none, and comprises of painless
placement of an electrical impedance belt around the lower thorax and of the
placement of a finger cuff to allow measurements of cardiac output by Nexfin.
Meibergdreef 9
1105 AZ Amsterdam
NL
Meibergdreef 9
1105 AZ Amsterdam
NL
Listed location countries
Age
Inclusion criteria
Hemodynamically stable patients coming for electrocardioversion because of atrial fibrillation
Exclusion criteria
o Age < 18 years
o Presence of a pacemaker
o Presence of an automatic cardiac defibrillator
o Presence of any implantable pumps
o History of chronic obstructive pulmonary disease (COPD - defined as a forced
expiratory volume in 1 second to a forced vital capacity ratio less than 0.65 and daily medication), restrictive pulmonary disease (evidence of chronic interstitial infiltration on chest radiograph), pulmonary thrombo-embolism, previous pneumectomy or lobectomy
o Known chronic or decompensated heart failure
o MET score <6
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL39752.018.12 |