To monitor the electric activity of the urinary bladder, and to localize the pacemaker, and the path of electric signal propagation of the detrusor muscle contractions.
ID
Source
Brief title
Condition
- Bladder and bladder neck disorders (excl calculi)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Detection of recordable electric activity of the urinary bladder.
Secondary outcome
To localize the pacemaker, and the path of electric signal propagation of the
detrusor muscle contraction in patients with OAB syndrome.
Background summary
Electric activity in the form of slow waves and action potentials has been
recorded from the urinary bladder in humans and animals using surface EMG
electrodes. The electric activity of the overactive bladder (OAB) syndrome has
been shown to be dysrhythmic. The cause of the dysrhythmic pattern was ascribed
to an abnormal pacemaker presumably located in the dome of the urinary bladder.
Sequential activation mapping supported by three-dimensional (3D)
electroanatomic mapping systems is widely used to reconstruct the 3D spread of
electrical activation throughout cardiac chamber anatomies.
Study objective
To monitor the electric activity of the urinary bladder, and to localize the
pacemaker, and the path of electric signal propagation of the detrusor muscle
contractions.
Study design
Feasibility study
Study burden and risks
Some mild discomfort might be experienced by the patient on introducing the
catheters.
Geert Grooteplein zuid, Nijmegen 10
Nijmegen 6500HB
AF
Geert Grooteplein zuid, Nijmegen 10
Nijmegen 6500HB
AF
Listed location countries
Age
Inclusion criteria
Adult patients > 18 year old, with Overactive bladder symptoms.
Exclusion criteria
Patients with previous bladder surgery
Patients with urinary tract infection
Female Patients with severe genital prolapse
Pregnency
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL46832.091.13 |