The objective of the present study is to obtain a better understanding of tonic dystonia by quantification of the motor and sensory characteristics of the condition, and to assess the relationship between both these parameters. Specifically, this…
ID
Source
Brief title
Condition
- Movement disorders (incl parkinsonism)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
1) Accuracy of joint position sense and motion
2) Selectivity of muscle activation.
3) Recognition of hand laterality.
4) Sensory function including two-point-discrimination, vibration sense, pain
threshold of muscles.
Secondary outcome
None.
Background summary
Background: Dystonia is a poorly understood disorder characterized by a
decrease or loss of voluntary muscle control associated with decreased
inhibition, changes in sensory processing and problems in sensorimotor
integration. Uncovering the interrelations among these aspects will likely
contribute to a better understanding of the condition. Dystonia is the most
frequently encountered movement disorder after peripheral trauma and frequently
occurs in the context of Complex Regional Pain Syndrome.
The study is expected to yield valuable information regarding differences in
sensory and motor processing between patients and controls. Additionally,
knowledge on the influence of sensory function on motor performance may not
only lead to a better insight in the sensorimotor integration in dystonia, but
may provide clues on how to use motor paradigms, sensory stimuli and sensory
manipulation to improve motor performance in patients with tonic dystonia. The
results are expected to raise new research questions which may instigate
follow-up research.
Study objective
The objective of the present study is to obtain a better understanding of tonic
dystonia by quantification of the motor and sensory characteristics of the
condition, and to assess the relationship between both these parameters.
Specifically, this study aims to further our understanding of the
voluntary-automatic dissociation phenomena and the processes underlying
coherence entrainment in these patients. To this end, both intentional and
unintentional sensorimotor integration is examined.
Study design
Cross-sectional case-control design.
Study burden and risks
The assessment procedure involves the completion of questionnaires (which will
take approximately 15 minutes) and the performance of motor tasks
(approximately two hours). Some fatigue in patients may be expected. Some
temporary discomfort in patients (due to the length of the protocol) cannot be
ruled out completely.
Albinusdreef 2
Leiden 2333 ZA
NL
Albinusdreef 2
Leiden 2333 ZA
NL
Listed location countries
Age
Inclusion criteria
Male or female patients diagnosed with CRPS with or without tonic dystonia of one or both upper extremities who are 18 years or older, have command of the Dutch language and are registered at the LUMC.
Exclusion criteria
mobile dystonia; known genetic form of dystonia, e.g. DYT1-DYT17, Wilson*s disease; lesions or diseases of the central nervous system (e.g. as a result of head trauma); implantation of drug-delivery pump for intrathecal baclofen or other spasmolytic medication.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL29310.058.09 |