How does motor fatigue influence the cognitive functioning of patients with MS and how does this interaction compare to that in healthy controls?
ID
Source
Brief title
Condition
- Demyelinating disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary parameters are the number of accurate responses to the CRT and the
reaction times of these reactions.
Secondary outcome
Maximal voluntary contraction (MVC), decrease in force during fatigue.
Background summary
Fatigue is one of the most common complaints in MS and can influence the
execution of daily tasks. The cause of the fatigue is not yet known (Tartaglia,
2004). In healthy people, fatigue of the central nervous system can be induced
by repetitive activation of a small hand muscle. (Zijdewind et al, 1998, 1999
en 2001). This fatigue also results in secundary cognitive problems (Lorist et
al, 2002; van Duinen et al 2005, Zijdewind et al, 2006). The study of the
underlying central mechanisms of fatigue has been given relatively little
attention. The goal of this research is to investigate the interaction between
motor and cognitive functioning during a fatiguing motor task with a
double-task paradigm. Previous research has shown that increasing fatigue
causes a decrease of performance on the secundary (cognitive) task (Lorist et
al, 2002; van Duinen et al, 2005; Zijdewind et al, 2006). The current study
will investigate whether this is true for MS patients as well. We expect that
patients, just as controls, will perform worse as a result of the dual-task
paradigm, and that patients will have a longer recovery period in comparison to
the healthy controls.
Study objective
How does motor fatigue influence the cognitive functioning of patients with MS
and how does this interaction compare to that in healthy controls?
Study design
The research consists of three sessions. During the first session, the strength
(using a force recorder) and muscle activity (using EMG-electrodes) of the
abductor of the right index finger (FDI) are measured . De subject is asked to
perform a cognitive 2-choice reaction time task (CRT), alone or simultaneously
with a motor task.
Intervention
Fatigue task
Study burden and risks
No risk, time investment for the subject 3*1.5 hours is 4,5 hours.
A.Deusinglaan 1
Groningen 9713 AV
NL
A.Deusinglaan 1
Groningen 9713 AV
NL
Listed location countries
Age
Inclusion criteria
Relapsing-remitting multiple sclerosis
EDSS < 5,5
Sufficient hand function to operate the force recorder
Righthandedness
Informed consent
Exclusion criteria
Psychiatric disorder
Depression
Neurological disorder other than MS
EDSS >= 5,5
Hearing disorder
Medication that influences (subjective) fatigue or force production (Amantadine, Amytryptiline, Pemoline, Tizanidine, Baclofen, Benzodiazepines, Potassium channel blockers, or modafinil. Or use of prednisolon in the past 6 weeks).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL32399.042.10 |