The first aim of this study is to determine the prevalence of cognitive impairment in COPD patients compared with persons without COPD and to compare cognitive functioning between patients referred by their general practitioner, patients referred by…
ID
Source
Brief title
Condition
- Bronchial disorders (excl neoplasms)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Raw scores on the different subtest of the neuropsychological test battery and
5 compound scores for the cognitive domains: motor speed, memory, cognitive
flexibility, planning and general cognitive functioning (cognitive index).
Secondary outcome
*demographics: age, level of education and social status;
*clinical characteristics:
-general psychological functioning: Symptom Checklist-90, Hospital Anxiety and
Depression scale, Beck Depression Inventory, Utrecht coping list, Dutch
personality questionnaire en St George's Respiratory Questionnaire.
-other clinical characteristics: blood gasses, comorbidities (Charlson
comorbidity index), pulmonary function, diffusion capacity, saturation measure,
Obstructief Slaap Apneu Syndroom, medication, oxygen therapy, smoking
behaviour, Body Mass Index, knowlegde about the lung disease and exercise
capacity (6-minute walking distance test).
*problematic activities of daily life ( *Canadian Occupational Performance
Measure*).
* patient information needs (Lung Information Needs Questionnaire).
* enablement to participate as an active partner in health care (Patient
Enablement Instrument en Partner in Health scale);
* expectations and views of the caregiver with respect to participation of the
patient as an active partner in health care (Clinician Support for Patient
Activation Measure]).
Background summary
Patients with Chronic Obstructive Pulmonary Disease (COPD) may experience
dyspnoea, fatigue and problems in daily functioning, despite optimal
pharmacological treatment. It is important that patients follow a number of
precepts in order to minimize the consequences of the illness. Before a patient
is willing to follow the precepts, a patient needs to experience that the new
behaviour yields more advantages, compared to the old behaviour. Patients need
specific cognitive abilities in order to make a considered choice. Previous
research suggests that the cognitive functions of COPD patients may be
impaired. However, results of previous research are disputable. To date,
remains unclear which clinical characteristics are related to cognitive
functioning in COPD patients and whether and to what extent cognitive
functioning is related to daily functioning, health status and the outcome of
pulmonary rehabilitation.
Study objective
The first aim of this study is to determine the prevalence of cognitive
impairment in COPD patients compared with persons without COPD and to compare
cognitive functioning between patients referred by their general practitioner,
patients referred by their chest physician and patients referred for pulmonary
rehabilitation. The second aim is to study the clinical characteristics of COPD
patients with cognitive impairment. The third aim is to assess whether and to
what extent cognitive functioning is related to daily functioning in COPD
patients entering pulmonary rehabilitation. The fourth aim is to assess whether
and to what extent cognitive functioning may influence important outcome
parameters of pulmonary rehabilitation: general psychological functioning,
knowledge about COPD, daily functioning and exercise capacity. The fifth aim is
to study the needs for information and possibility to participate as an active
partner in health care.
Study design
This study consists of two parts: an observational comparative study and an
observational study with repeated measurements.
Study burden and risks
This study will provide more insight in cognitive functioning of patients with
COPD. This insight will help us to improve management programmes for COPD
patients. Risks for participations are minimal. Patients have no individual
benefit from participation.
P. Debeyelaan 25
6202 AZ Maastricht
NL
P. Debeyelaan 25
6202 AZ Maastricht
NL
Listed location countries
Age
Inclusion criteria
Patients:
*Diagnosis: COPD according to the Global Initiative For Chronic Obstructive Lung Disease (GOLD) definition. ;Matched control group:
*partner, brother or sister of an included patient
*smoking status comparable with smoking status form included patient (current smoker; non smoker; former smoker).
Exclusion criteria
Patients:
*Patient is not clinically stable during 4 weeks preceding enrolment
*Previous diagnosis of dementia
*Patient does not speak Dutch well enough to participate
*At the moment of testing, patients who were referred by their general practitioner but are also treated by a chest physician or are currently referred for pulmonary rehabilitation.
*At the moment of testing, patients who were referred by the chest physician but are also referred for pulmonary rehabilitation. ;Matched control group:
*Diagnoses of COPD or Asthma
*Previous diagnosis of dementia
*Participant does not speak Dutch well enough to participate
*Age of the matched control differ more than 10 years from the age of the patient for who he/she was matched
*level of education of the matched control differ more than 3 levels from the level of education for who he/she was matched
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL36715.068.11 |