To examine the impact of prolonged (walking) exercise on cardiac and vascular function in older humans
ID
Source
Brief title
Condition
- Cardiac disorders, signs and symptoms NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Diastolic/systolic cardiac function (measured using echocardiography) and
vascular function (measured as brachial artery flow-mediated dilation and pulse
wave velocity) are primary outcome parameters.
Secondary outcome
Pulmonary function (spirometry), muscle function and cardiac troponin will be
included as secondary outcome parameters.
Background summary
Rationale: Walking represents a moderate-intensity exercise, which can be
performed for several hours. This makes (prolonged) walking exercise suitable
for various (clinical) populations and is frequently performed by older
individuals. Prolonged, strenuous exercise in healthy young subjects represents
a strong physiological strain. For example, strenuous exercise leads to acute
impairments in cardiac and vascular function in healthy young populations. To
date, relatively little is known about the acute impact of prolonged,
moderate-intensity exercise on cardiovascular, pulmonary and muscular responses
in older humans.
Study objective
To examine the impact of prolonged (walking) exercise on cardiac and vascular
function in older humans
Study design
Observational study
Study burden and risks
Walking is not associated with serious health risks. Actually, regular physical
activity such as walking exercise protects against cardiovascular disease/risk.
Furthermore, our primary outcome measures relate to non-invasive measurement of
cardiac, and vascular function. Our secondary outcome measures will be
determined from a venous blood sample (i.e. cardiac troponin), which is
associated with a minor risk for haemorrhage (5%) or the non-invasive
spirometry (pulmonary function), respectively.
Philips van Leijdenlaan 15
Nijmegen 6525 EX
NL
Philips van Leijdenlaan 15
Nijmegen 6525 EX
NL
Listed location countries
Age
Inclusion criteria
- In preparation for the Nijmegen 4-Day Marches 2014
- Older than 60 years
Exclusion criteria
- History of cardiovascular or cerebrovascular complication (e.g. myocardial infarction, cerebrovascular accident)
- History of (preventive) cardiac surgery (e.g. coronary artery bypass surgery, percutaneous coronary intervention)
- Younger than 60 years
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL47480.091.13 |