Primary Objective:To investigate the feasibility of studying of the effects of 6 days of predominantly prolonged sitting on cardiometabolic health in young adults.Secondary Objective: To collect preliminary data on the effects of 6 days of…
ID
Source
Brief title
Condition
- Glucose metabolism disorders (incl diabetes mellitus)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main outcome measures of this pilot study are blood pressure and plasma
levels of glucose, insulin, triglycerides and NEFA in all blood samples.
Secondary outcome of this pilot study is the autonomic nerve
Secondary outcome
N.A.
Background summary
Recent preliminary experimental findings in obese adults on the acute effects
of prolonged sitting show a detrimental increase in triglycerides prolonged
sitting during a 7-hr sitting day compared to a non-sitting day. Breaking up
the 7-hr sitting every 20min can attenuate these detrimental acute effects on
glucose metabolism. In the first part of our pilot study we additionally
demonstrated in healthy young adults, that hourly interruptions in sitting can
also attenuate these detrimental acute effects. However, no evidence exists on
the deterimental effects of repeated uninterrupted sitting. This information is
highly necessary to obtain insight in the detrimental health effects of a
sedentary lifestyle, e.g. reflecting daily life.
Study objective
Primary Objective:
To investigate the feasibility of studying of the effects of 6 days of
predominantly prolonged sitting on cardiometabolic health in young adults.
Secondary Objective:
To collect preliminary data on the effects of 6 days of predominantly prolonged
sitting on cardiometabolic health in young adults.
Study design
Pilot study involving two laboratory sitting days, similar to the prolonged
sitting condition in the first part of this pilot study. In addition, each
participants will complete 6 days of 'lifestyle sitting', consisting of
reducing the interruptions in sitting time as much as possible, in between the
two sitting days.
Study burden and risks
Participants will visit the laboratory on two occasions (two laboratory sitting
days), having fasted for at leas 10 hours. Anthropometrics (e.g. weight,
height, waist- and hip circumference, body fat percentage) will be measured at
baseline. Venous blood will be collected at baseline and hourly during the
8-hour laboratory days (9 samples in total for each sitting day), using an
in-dwelling catheter. At similar time points blood pressure will be measured
using an automatic oscillometric method. Participants will complete 6 days of
lifestyle sitting in between the two laboratory sitting days. After completion
of this pilot study, participant will be motivated to minimize their time spent
on prolonged sitting and increase their time spent on physical activity. They
will receive a pedometer, which they can keep, in order to increase motivation.
There is no risk associated with participants in this pilot experiment.
van der boechorststraat 7
1081 BT, Amsterdam
NL
van der boechorststraat 7
1081 BT, Amsterdam
NL
Listed location countries
Age
Inclusion criteria
Being apparently healthy, having an active lifestyle (i.e. at least 30 minutes moderate to vigorous physical activity at each day of the week), aged 18-23, Dutch or English speaking, and signed informed consent.
Exclusion criteria
Known physical activity contraindications, major illness/injury (acute or chronic) or physical problems that may limit the ability to perform the experiment.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL37053.029.11 |