In this study we will provide reference values using the single occlusion technique in healthy infants aged 2 months - 1 year.
ID
Source
Brief title
Condition
- Lower respiratory tract disorders (excl obstruction and infection)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameter is the single occlusion technique.
Secondary outcome
Besides lung function, we will measure body weight and body height.
Background summary
Wheezing illnesses are the most common cause of morbidity and mortality in
infancy and childhood and have a large impact on health care. (Katier et al.
zie intro)
It is important to recognise the child that is at risk for severe acute or
chronic respiratory disease as early as possible during infancy or childhood.
Adequate treatment and prevention might prevent long term morbidity.
Katier et al. showed that feasibility and variability of lung function testing
using the SOT is acceptable for use in large populations of healthy neonates
and infants in routine care. In another study Katier et al. provided reference
values for healthy neonates. Participants of this study were recruited as part
of the Whistler-project and were all < 2 months. No reference values exist in
children > 2 months.
Study objective
In this study we will provide reference values using the single occlusion
technique in healthy infants aged 2 months - 1 year.
Study design
This study has a cross-sectional design. The participants will be derived from
day nurseries which are willing to participate.
Study burden and risks
There are no risks associated with participation in this study. There is no
benefit for the children in participating to this study and participation is
completely voluntary. We will conduct our study according to the code of
conduct in case of resistance of the Dutch Assocation of Paediatrics (NVK).
Lundlaan 6
3508 AB Utrecht
NL
Lundlaan 6
3508 AB Utrecht
NL
Listed location countries
Age
Inclusion criteria
Healthy children at a day nursery
Exclusion criteria
- Children with a history of neonatal respiratory disease.
- Children with a disease which could influence pulmonary function, like thoracic malformations or abnormal growth.
- Children with gestational age <36 weeks
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL36892.041.11 |