To determine the differences in EEG properties between delirious and non-delirious (ICU) cardiothoracic surgery patients surgery and to determine the EEG deviation where the largest differences appear. Secondary objective is to determine the…
ID
Source
Brief title
Condition
- Deliria (incl confusion)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The folowing EEG properties are calculated for different EEG deviations:
the absolute power of delta (0.5-4), theta (4-8 Hz), alpha (8-13 Hz) and beta
(13-20 Hz);
the relative power (% of total power of EEG) of delta (0.5-4), theta (4-8 Hz),
alpha (8-13 Hz) and beta (13-20 Hz);
the peak power;
the mean power;
the peak frequency
the centroid frequency.
Secondary outcome
Results of the psychotic symptoms questionnaire
Results of the evaluationform
Background summary
Delirium is a common disorder in the intensive care unit (ICU), with a reported
incidence up to 80%. However, delirium is poorly recognized. In previous
studies, electroencephalography (EEG) appeared to be a sensitive tool for the
diagnosis of delirium. However, this knowledge was never implemented in a
continuous monitoring system. Before a continuous monitoring system can be
developed, it is important to determine which EEG characteristics are most
affected affected and at which EEG deviation they are most affected. To study
EEG characteristics we first focus on a uniform population of cardiothoracic
surgery patients. Furthermore we want to study the feasibility of a psychotic
symptom questionnaire, because psychotic symptoms can be related to eye
movements, which can also be measured by EEG.
Study objective
To determine the differences in EEG properties between delirious and
non-delirious (ICU) cardiothoracic surgery patients surgery and to determine
the EEG deviation where the largest differences appear. Secondary objective is
to determine the feasibility of the psychotic symptoms questionnaire in 11
delirious patients.
Study design
The study design is a prospective, descriptive, diagnostic study.
Study burden and risks
For the majority of patients the only burden is a standard, 30 minute EEG.
However, eleven delirious patients will also receive an orally administered
questionnaire which will take approximately 2-10 minutes. The questionnaire
will be administered during the EEG preparation, and therefore will not add
extra time to the investigation. As there are no risks and small benefits for
the individual patient, the risk-benefit is positive. Delirious patients that
participate in this study can be diagnosed with non-convulsive epileptic
seizures and receive on time an adequate treatment, which otherwise could be
delayed.
The goal of this study is to find EEG parameters which are specific for
delirium. These EEG parameters can be used to diagnose delirium more adequately
and thereby guide to better treatment of these patients. Without participation
of patients with delirium it is not possible to determine EEG parameters which
can be used for diagnosing delirium. Therefore, this study is group-related.
Heidelberglaan 100
Utrecht 3508 GA
NL
Heidelberglaan 100
Utrecht 3508 GA
NL
Listed location countries
Age
Inclusion criteria
Patients admitted in the University Medical Centre Utrecht after cardiothoracic surgery.
informed consent
Exclusion criteria
No informed consent
Other cerebral disorder than delirium
RASS score lower than -3
Use of haloperidol is not an exclusion criterion.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL35576.041.11 |