1/ To demonstrate endo-epicardial electrical dissociation (EED) in human atrial fibrillation.2/ To investigate whether occurrence of EED contributes to formation of CFAEs.3/ To study the epicardial conduction pattern above areas with endocardial…
ID
Source
Brief title
Condition
- Cardiac arrhythmias
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
• Presence of EED
• Number, width and origin of waves overlaying CFAE areas.
Secondary outcome
• The correlation between EED index and number CFAEs
• Difference of EED index between paroxysmal AF (PAF group) and persistent AF
(AF group)
• Difference of number of CFAEs between paroxysmal AF (PAF group) and
persistent AF (AF group)
• The correlation between CFAE and number and width of fibrillatory waves
• Identification of different types of CFAE
• Correlation of types of CFAE with PAF and AF.
Correlation of the complexity of atrial fibrillation using
invasive and semi-invasive methods.
Background summary
Atrial Fibrillation (AF) is the most common sustained arrhythmia. The
pathophysiological mechanisms leading to onset and perpetuation of AF are still
unclear. Recently, our group demonstrated dissociation of electrical activity
during AF between the endocardial and epicardial layer of the atria in goats.
This endo-epicardial dissociation (EED) leads to AF stabilization by providing
more functional surface for fibrillation wavelets to coexist and represents a
prerequisite condition for transmural conduction with reactivation of atrial
myocardium in the opposing layer of the atrial wall. Demonstration of EED in
humans is lacking so far.
On the other hand, new strategies are developed in treatment of AF by
radiofrequency (RF) ablation. More and more, areas of Complex Fractionated
Atrial Electrograms (CFAEs), supposingly involved in the perpetuation of AF,
are targeted. In some clinical studies, CFAE ablation increases the success
rate of RF ablation procedures to convert persistent AF to sinus rhythm.
However, studies unmasking the origin and true physiological meaning of CFAEs
are lacking.
Study objective
1/ To demonstrate endo-epicardial electrical dissociation (EED) in human atrial
fibrillation.
2/ To investigate whether occurrence of EED contributes to formation of CFAEs.
3/ To study the epicardial conduction pattern above areas with endocardial
CFAEs.
Study design
Prospective non randomized observational study of consecutive patients who
undergo AF ablation in the hybrid room.
Study burden and risks
Except extra time to do measurements, there is no additional risk for
participants, as well as no individual benefit expected.
Peter Debyelaan 25
6229 HX Maastricht
NL
Peter Debyelaan 25
6229 HX Maastricht
NL
Listed location countries
Age
Inclusion criteria
paroxysmal or persistent AF
Exclusion criteria
Thoracoscopic Redo procedure
Patients who are not will competent
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL36517.068.11 |