To assess the impact of OH on cerebral perfusion and function in severe OH in AF (n=10) and healthy controls (n=10).
ID
Source
Brief title
Condition
- Structural brain disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main outcome measure is the change in total SART error score in the
standing vs. the supine position.
Secondary outcome
changes in cerebral perfusion and bloodpressure upon standing.
Background summary
Orthostatic hypotension (OH) affects up to 30% of all elderly people and is
associated with the development of white matter lesions, stroke and vascular
dementia. These findings suggest that OH may cause permanent sequelae through
cerebral hypoperfusion. Supporting this view, orthostatic cognitive impairment
is a common symptom of severe OH due to autonomic failure (AF). Studying
orthostatic cognitive and circulatory changes may prove fruitful to elucidate
the pathophysiology of OH-related cerebral damage.
Study objective
To assess the impact of OH on cerebral perfusion and function in severe OH in
AF (n=10) and healthy controls (n=10).
Study design
Single center, observational pilot study.
Study burden and risks
All measurements are non-invasive and without discomfort. Standing may elicit
syncope. Given the short duration of the standing test, the risk for syncope is
low. The participants are instructed to report prodromal symptoms of syncope,
so they can be seated; hereby loss of consciousness can be prevented. In
addition, the investigator can intervene in case the BP measurements are
decreasing and thus a syncopal reaction is expected.
Albinusdreef 2
Leiden 2300 RC
NL
Albinusdreef 2
Leiden 2300 RC
NL
Listed location countries
Age
Inclusion criteria
Both groups (autonomic failure, controls):
- Age> 18 year
Autonomic failure:
- Symptomatic orthostatic hypotension
Exclusion criteria
both groups:
- MMSE <24;-Controls:
- Diabetes type 1 or 2
- Parkinson's disease
- heartfailure
- complaints of Orthostatic hypotension
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL35521.058.12 |