The primary study objective is to assess whether TCS in cataract patients is a predictor of postoperative VA and if so, whether it is a better predictor than currently routinely used measurements, as represented by preoperative VA measurement…
ID
Source
Brief title
Condition
- Vision disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Temporal contrast sensitivity
Postoperative visual acuity
Secondary outcome
Presence and extent of cataract (LOCS III score)
Presence and extent of AMD (AREDS score)
Preoperative visual acuity
Refractive error
Straylight
Background summary
When cataract leads to impairment of visual acuity (VA), one of the goals of
cataract surgery is to restore VA. Co-morbid eye- or brain disease (e.g.
glaucoma, age-related macular degeneration (AMD), retinitis pigmentosa or
amblyopia) may preclude optimal VA after cataract surgery. Currently, no
objective measurement exists to assess whether impaired VA is solely due to
cataract, or at least partly attributable to pathology of retinal or neuronal
processing. If such a measurement would exist, it might be possible to more
accurately predict VA after cataract surgery.
Temporal contrast sensitivity (TCS) comprises the sensitivity of the visual
system to contrast change in time (as opposed to contrast change in space).
Studies have shown that TCS decreases when retinal pathology is present,
whereas impairment of eye optics (e.g. cataract) have no influence on TCS. This
suggests that TCS has high sensitivity and specificity for pathology of retinal
or neuronal processing and that a correlation exists between preoperative TCS
and optimal VA that is feasible after cataract surgery. If this is true, TCS
could be applied to predict postoperative VA in surgically treated cataract
patients.
Study objective
The primary study objective is to assess whether TCS in cataract patients is a
predictor of postoperative VA and if so, whether it is a better predictor than
currently routinely used measurements, as represented by preoperative VA
measurement through multiple pinhole. Secondary objectives are (1) to
investigate the influence of disturbed eye optics (cataract patients) and
retinal pathology (AMD patients) on TCS, and (2) to assess (intraobserver)
repeatability and reproducibility of the TCS measurement.
Study design
Prospective non-interventional cohort study.
Study burden and risks
There are no benefits for the participant. Risks are negligible. Burden
comprises two non-invasive measurement sessions lasting approximately 30-60
minutes per session.
Schiedamse Vest 180
Rotterdam 3011 BH
NL
Schiedamse Vest 180
Rotterdam 3011 BH
NL
Listed location countries
Age
Inclusion criteria
Age >= 65
Scheduled for cataract surgery
With or without dry AMD as ophthalmic co-morbidity
Informed consent
Exclusion criteria
Amblyopia
Corneal haze
Guttata
Diabetic maculopathy / retinopathy
Epiretinal membrane
Glaucoma
Uveitis
Opthalmic vessel occlusion
Retinal detachment / defect
Vitrectomy
Trauma
Corneal surgery
Refractive surgery
Cystoid macular edema in other eye
Wet AMD
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL44741.078.13 |