With this research project we aim to investigate the time course and relationship between psychotic, obsessive-compulsive and depressive symptoms and the influence of environmental and individual factors on the course of symptom severity and…
ID
Source
Brief title
Condition
- Schizophrenia and other psychotic disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Web-based assessments with monthly assessment intervals over 12 months
including psychopathology (psychosis, OCS and affective symptoms),
environmental and individual factors (such as life events and coping
strategies).
Secondary outcome
Subsequent use of the experience sampling method (ESM) over a period of 6 days
in a subgroup of patients with a non-affective psychosis, who recently reported
changes in OCS severity.
Background summary
A frequent co-morbidity in schizophrenia are obsessive-compulsive symptoms
(OCS), which are reported by more than 20% of patients and are associated with
additional impairments, more severe depressive symptoms, and poor social
outcome (Fenton and McGlashan, 1986;de Haan et al., 2012). Recently, results of
prospective studies revealed a high variability of OCS severity in patients
with non-affective psychosis over time. In addition associations between
symptom changes in OCS, psychotic and affective symptoms were found (de Haan et
al., 2012;Schirmbeck et al., 2013). Findings are however limited by long
intervals between assessments, allowing no statements on causal interactions
and leaving the pathogenic understanding of this co-occurence unresolved.
Study objective
With this research project we aim to investigate the time course and
relationship between psychotic, obsessive-compulsive and depressive symptoms
and the influence of environmental and individual factors on the course of
symptom severity and interactions.
In more detail the following aims have been formulated:
1. Understanding the interplay between symptoms: As the primary endpoint, we
want to elucidate the course and interaction of psychotic, obsessive-compulsive
and affective symptoms over time.
2. Identifying the effect of environmental factors and psychological mechanisms
on symptom severity and interaction: As secondary endpoints we want to evaluate
reactivity to environmental factors (daily hassles, life events, medication)
and the influence of individual mechanisms (metacognitive believes and coping
strategies) on symptom fluctuation and interaction.
Study design
Two complementary assessment approaches will be conducted within an
observational prospective design.
Study burden and risks
The web-based investigation will take approximately one hour to complete at
each assessment time. In addition, patients who take part in the subsequent
experience sampling method will invest another 2.5 hours of total assessment
time. Neither risks nor benefits are attached to this study.
Meibergdreef 5
Amsterdam 1105 AZ
NL
Meibergdreef 5
Amsterdam 1105 AZ
NL
Listed location countries
Age
Inclusion criteria
1) former GROUP participants, who have given informed consent to be contacted for future studies
2) Age range of 18 to 60 years
3) Diagnosis of non-affective psychotic disorder according to the Diagnostic and Statistical Manual of Mental Disorders
4) Previously reported co-morbid obsessive-compulsive symptoms
5) Good command of the Dutch language
6) Able and willing to give written informed consent
7) Internet access.
Additional Inclusion criterion for the experience sampling approach will be the change in OCS severity during the previous month. Significant change is defined as a delta Y-BOCS score of 5 or more.
Exclusion criteria
1) IQ<60
2) Evidence of psychotic symptoms precipitated by an organic cause
3) Psychotic symptoms resulting from alcohol or drug dependence
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL46405.018.13 |