The objective of the study is to reveal the neurocognitive mechanisms by which mindful eating training acts. Moreover, the 1-year follow-up analysis will enable the comparison of mindful eating training with educational nutritional health methods on…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
does not involve patient population, but healthy individuals who would like to change their eating pattern
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
We will assess the difference in performance (i.e. error rates and reaction
times) and brain activity and connectivity (using fMRI) in prefrontal cortex
control (i.e. attentional bias to food-related words and negatively valenced
words), and striatum (i.e. food and monetary reward cue responses) before
versus after training, dependent on training type.
Secondary outcome
Secondarily, we will obtain weight and waist-hip ratio measurements and
questionnaire data at every lab visit (incl. 1-year follow-up) to assess the
effects of the training on weight and eating behaviour and general reward
sensitivity..
Background summary
Obesity has reached epidemic proportions globally, and is a major contributor
to the worldwide burden of chronic disease and disability. High-calorie,
palatable food is not only a source of nutrition but also a strong reward. Food
cues in the environment can trigger a habitual response to eat even when we are
not hungry. Subsequently, habitual eating (*on autopilot*) is insensitive to
internal signals of satiety during consumption. The vulnerability to overeat
might be caused by a hyperactive cue-evoked dopamine reward/habit system in the
striatum or attenuated prefrontal cortex involvement in goal-directed control
opposing habitual behavior.
An increasingly popular method to counteract the habitual act of overeating is
mindfulness training, aimed at increasing awareness to internal and external
signals. Preliminary studies suggest it is effective in reducing habitual food
intake, but it is unclear how: does it decrease striatal reward cue responses
or enhance prefrontal cortex control?
Study objective
The objective of the study is to reveal the neurocognitive mechanisms by which
mindful eating training acts. Moreover, the 1-year follow-up analysis will
enable the comparison of mindful eating training with educational nutritional
health methods on preventing weight gain.
Study design
Subjects will be pseudo-randomly assigned to a behavioral intervention or an
active-control intervention, and will be tested (observationally with fMRI)
both before and after the behavioral intervention.
Intervention
Subjects will follow either a mindful eating training or an educational cooking
training (active control). Both trainings will consist of 8 weekly 2.5h group
sessions, 45-minute daily homework and a silent or balance day, respectively.
Study burden and risks
The subjects are not exposed to any risks when participating in this study.
Subjects will come to the Donders Institute four times: 1x for an intake (1.5h,
no scanning), 2x for a test day (before and after the intervention; 4h each, of
which 1h in the MR scanner), and once more for the 1-year follow-up (1h, no
scanning). In addition, the intervention will take a considerable amount of
time (see heading "Intervention" above).
Kapittelweg 29
Nijmegen 6525 EN
NL
Kapittelweg 29
Nijmegen 6525 EN
NL
Listed location countries
Age
Inclusion criteria
- Age: 18 - 55 years old
- BMI: 19 - 35
- Right-handed
- Motivated to change their eating pattern, i.e.willing to spend the amount of time required by the training programs
Exclusion criteria
- MRI contraindications
- (History of) clinically significant diseases
- (History of) signiificant neurological or psychiatric disorders
- Regular use of drugs and psychotropic medication
- Current strict dieting
- Experience with MBSR or MBCT course
- Food allergy to any ingredients used in the food rewards
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL43884.091.13 |
| OMON | NL-OMON19913 |
| OMON | NL-OMON23364 |