To develop and validate transplant models of vitiligo and atopic dermatitis for drug testing.
ID
Source
Brief title
Condition
- Other condition
- Skin vascular abnormalities
Synonym
Health condition
Developing human skin disease models
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
N.A.
Secondary outcome
N.A.
Background summary
There is a need for models of skin diseases for testing and developing new
therapies
Study objective
To develop and validate transplant models of vitiligo and atopic dermatitis for
drug testing.
Study design
Volunteers will donate skin biopsies (3 x 5 mm diameter) and blood (27 ml)
which will be used in a mouse transplant model.
Study burden and risks
N.A.
Galileiwg 8
Leiden 2333BD
NL
Galileiwg 8
Leiden 2333BD
NL
Listed location countries
Age
Inclusion criteria
Volunteers (male/female) are 18 years or older, suffering from psoriasis vulgaris, vitiligo or atopic dermatitis.
Exclusion criteria
Volunteers cannot be taking immune-modulating drugs.
Volunteers cannot have UV/light therapy.
If donating lesional skin biopsies then patients cannot use topical treatments up to 2 weeks before donating the biopsies (they can use placebo creams to treat dry skin).
Volunteers should not have problems with the Köbner phenomenom.
Volunteers should not be pregnant
Design
Recruitment
metc-ldd@lumc.nl
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL42861.098.13 |